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首页> 外文期刊>Expert opinion on biological therapy >Malaria vaccines: the case for a whole-organism approach.
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Malaria vaccines: the case for a whole-organism approach.

机译：疟疾疫苗：采用全生物方法的情况。

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BACKGROUND: Malaria is a significant health problem causing morbidity and mortality worldwide. Vaccine development has been an imperative for decades. However, the intricacy of the parasite's lifecycle coupled with the lack of evidence for robust infection-induced immunity has made vaccine development exceptionally difficult. OBJECTIVE: To review some of the key advances in the field and discuss potential ways forward for a whole-organism vaccine. METHODS: The authors searched PubMed using the words 'malaria and vaccine'. We searched for manuscripts detailing antigen characterisation and vaccine strategies with emphasis on subunit versus whole-parasite approaches. Abstracts were selected and relevant articles are discussed. The searches were not restricted by language or date. CONCLUSIONS: The early cloning of malaria antigens has fuelled rapid development of subunit vaccines. However, the disappointing results of clinical trials have resulted in reappraisal of current strategies. Whole-parasite approaches have re-emerged as an alternative strategy. Immunization using radiation or genetically attenuated sporozoites has been shown to result in sterile immunity and immunization with blood-stage parasites curtailed by antimalarials has demonstrated delayed parasitemia in rodent models as well as in human malaria.
机译：背景：疟疾是一个重大的健康问题，在世界范围内引起发病和死亡。几十年来，开发疫苗一直势在必行。然而，寄生虫生命周期的复杂性以及缺乏强有力的感染诱导的免疫力的证据，使得疫苗的开发异常困难。目的：回顾该领域的一些关键进展，并讨论全生物疫苗的潜在发展途径。方法：作者使用“疟疾和疫苗”一词搜索PubMed。我们搜索了详细描述抗原特性和疫苗策略的手稿，重点是亚基和全寄生方法。选择摘要并讨论相关文章。搜索不受语言或日期的限制。结论：疟疾抗原的早期克隆促进了亚单位疫苗的快速发展。但是，令人失望的临床试验结果导致对当前策略的重新评估。全寄生方法已作为一种替代策略重新出现。使用辐射或遗传减毒的子孢子进行的免疫接种已显示出无菌的免疫力，用抗疟疾药物抑制的血期寄生虫进行的免疫接种已证明在啮齿动物模型以及人类疟疾中的寄生虫病延迟。

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