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首页> 外文期刊>Expert opinion on biological therapy >Antigen-antibody immunogenic complex: promising novel vaccines for microbial persistent infections.
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Antigen-antibody immunogenic complex: promising novel vaccines for microbial persistent infections.

机译：抗原-抗体免疫原性复合物：有望用于微生物持续感染的新型疫苗。

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摘要

BACKGROUND: Persistent microbial infections are major public health problems worldwide. Immunotherapies have become an important treatment for persistent infections. With the increasing senescent population, low responsiveness to the current preventive vaccines is another challenge for control of infectious diseases. OBJECTIVE/METHODS: Active immunotherapy by antigen-antibody complexes (IC) is reviewed. RESULTS/CONCLUSIONS: IC have shown effects in an hepatitis B surface antigen positive transgenic mouse model by reducing HBsAg, inducing anti-HBs and initiating cytolytic responses. Phase I, IIA and IIB clinical trials in around 300 viral hepatitis B patients have shown promising results. The mechanisms of IC are mainly modulation of antigen uptake and antigen processing and antigen presentation by IC. The prospects for employing IC in treatment of other microbial persistent infections and for prevention in immunocompromized individuals are discussed.
机译：背景：持久性微生物感染是全球主要的公共卫生问题。免疫疗法已成为持续感染的重要治疗方法。随着衰老人口的增加，对当前预防性疫苗的低响应性是控制传染病的另一个挑战。目的/方法：综述了抗原-抗体复合物（IC）的主动免疫疗法。结果/结论：IC已通过降低HBsAg，诱导抗HBs和启动细胞溶解反应，在乙型肝炎表面抗原阳性转基因小鼠模型中显示出作用。在约300例乙型病毒性肝炎患者中进行的I，IIA和IIB期临床试验显示出可喜的结果。 IC的机制主要是通过IC调节抗原摄取和抗原加工以及抗原呈递。讨论了将IC用于治疗其他微生物持续性感染以及预防免疫功能低下个体的前景。

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