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首页> 外文期刊>Expert opinion on biological therapy >Stem cells and lung cancer: future therapeutic targets?
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Stem cells and lung cancer: future therapeutic targets?

机译：干细胞与肺癌：未来的治疗目标？

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In both the UK and USA more people die of lung cancer than any other type of cancer. Lung cancer's high mortality rate is also reflected on a global scale, with lung cancer accounting for more than 1 million deaths per year. In tissues with ordered structure such a lung epithelia, it is likely that the cancers have their origins in normal adult stem cells, and then the tumours themselves are maintained by a population of malignant stem cells - so-called cancer stem cells. This review examines both these postulates in animal models and in the clinical setting, noting that stem cell niches appear to foster tumour development, and that drug resistance can often be attributed to malignant cells with stem cell properties.
机译：在英国和美国，死于肺癌的人数均超过其他任何类型的癌症。肺癌的高死亡率也反映在全球范围内，肺癌每年导致超过100万人死亡。在具有有序结构的组织（如肺上皮）中，癌症很可能起源于正常的成年干细胞，然后肿瘤本身由一群恶性干细胞（所谓的癌症干细胞）维持。这篇综述检查了动物模型和临床环境中的这些假设，并指出干细胞壁ches似乎促进了肿瘤的发展，并且耐药性通常可以归因于具有干细胞特性的恶性细胞。

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