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Peptide-based vaccination for colorectal cancer.

机译：基于肽的大肠癌疫苗接种。

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Recently, the number of patients with colorectal cancer has been increasing. Although most patients with early colorectal cancer have a good prognosis, in the case of recurrent or metastatic disease, the prognosis is poor and most patients will ultimately die of cancer. Furthermore, the conventional treatment, such as chemotherapy or radiation therapy, occasionally can not be continued due to reasons of toxicity and/or poor response. Therefore, novel therapeutic optional approaches based on immunotherapy are being explored at present. This review describes and sums up the principles and the longstanding problems of peptide vaccine therapy, and demonstrates the results of clinical trials with colorectal cancer peptide vaccine therapy, including the authors' personal appraisal. In conclusion, the future prospects of peptide vaccine therapy are described.
机译：最近，结直肠癌的患者人数一直在增加。尽管大多数早期结直肠癌患者预后良好，但在复发或转移性疾病的情况下，预后较差，大多数患者最终会死于癌症。此外，由于毒性和/或不良反应的原因，常规治疗，例如化学疗法或放射疗法，有时不能继续进行。因此，目前正在探索基于免疫疗法的新型治疗可选方法。这篇综述描述并总结了肽疫苗治疗的原理和长期存在的问题，并展示了结直肠癌肽疫苗治疗的临床试验结果，包括作者的个人评价。总之，描述了肽疫苗治疗的未来前景。

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