• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Expert opinion on biological therapy >MicroRNAs in gastrointestinal cancer: Prognostic significance and potential role in chemoresistance
【24h】

MicroRNAs in gastrointestinal cancer: Prognostic significance and potential role in chemoresistance

机译：MicroRNAs在胃肠道癌症中的预后意义及其在化学耐药中的潜在作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: Although chemotherapy is an important therapeutic strategy for gastrointestinal cancer, its clinical effect remains unsatisfied due to drug resistance. Drug resistance is a complex multistep process resulting from deregulated expression of many molecules, including tumor suppressor genes, oncogenes and microRNAs (miRNAs). A better understanding of drug resistance-related miRNAs may eventually lead to optimized therapeutic strategies for cancer patients.Areas covered: This review summarizes the recent advances of drug resistance-related miRNAs in esophageal, gastric and colorectal cancer. Furthermore, this study envisages future developments toward the clinical applications of these miRNAs to cancer therapy.Expert opinion: Drug resistance-related miRNAs may be potentially predicting biomarkers that help guide individualized chemotherapy. Specific miRNAs and their target genes can be used as therapeutic targets by reversing drug resistance. More investigations should be performed to promote the translational bridging of the latest research into clinical application.
机译：简介：尽管化学疗法是治疗胃肠道癌的重要策略，但由于耐药性，其临床效果仍不令人满意。耐药性是一个复杂的多步骤过程，其产生于许多分子的表达失调，包括抑癌基因，致癌基因和microRNA（miRNA）。对耐药相关miRNA的更好理解可能最终会导致针对癌症患者的优化治疗策略。涵盖的领域：本综述总结了在食道癌，胃癌和结肠直肠癌中耐药相关miRNA的最新进展。此外，这项研究还展望了这些miRNA在癌症治疗中的临床应用的未来发展。专家意见：耐药相关的miRNA可能是潜在的预测生物标志物，有助于指导个体化化疗。通过逆转耐药性，特定的miRNA及其靶基因可以用作治疗靶标。应该进行更多的研究以促进将最新研究转化为临床应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号