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Technosphere insulin: inhaled prandial insulin

机译：Technosphere胰岛素：吸入性餐前胰岛素

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摘要

Introduction: Insulin therapy is a mainstay for treatment of diabetes mellitus; however, many barriers to insulin exist. Insulin human inhalation powder (technosphere insulin) is a new FDA-approved alternative to subcutaneous bolus insulin.Areas covered: This is an overview of technosphere insulin (TI). Pharmacokinetics, clinical efficacy, safety and tolerability are discussed.Expert Opinion: TI is more quickly absorbed than subcutaneous insulin therapies and has a shorter duration of action. It appears to be noninferior compared with subcutaneous insulin regimens, and is associated with less hypoglycemia. Thus, it may serve as an alternative insulin agent in patients reluctant to administer multiple subcutaneous injections of insulin daily or in patients who experience late postprandial hypoglycemia with subcutaneous insulin. Cough is the most common side effect, but tends to be mild and transient. A small decrease in the forced expiratory volume has been demonstrated, but does not appear to progress and is reversible. Patients should have periodic pulmonary function tests. TI is contraindicated in patients with chronic lung disease. The long-term risk of lung cancer is being monitored but at this point does not appear to be higher than the expected incidence of lung cancer in this population.
机译：简介：胰岛素疗法是治疗糖尿病的主要手段。但是，胰岛素存在许多障碍。胰岛素人体吸入粉（technosphere胰岛素）是FDA批准的一种新的替代皮下推注胰岛素的替代品。涵盖范围：这是Technosphere胰岛素（TI）的概述。讨论了药代动力学，临床疗效，安全性和耐受性。专家意见：TI比皮下胰岛素疗法吸收更快，作用时间更短。与皮下胰岛素治疗方案相比，它似乎并不逊色，并且与低血糖症相关。因此，在不愿每天多次皮下注射胰岛素的患者中或在皮下注射胰岛素的餐后低血糖晚期患者中，它可作为替代胰岛素药物。咳嗽是最常见的副作用，但往往是轻度和短暂的。已经证明，呼气量略有减少，但似乎没有进展并且是可逆的。患者应定期进行肺功能检查。 TI禁止用于患有慢性肺病的患者。目前正在监测肺癌的长期风险，但是目前看来，该风险还没有高于该人群中肺癌的预期发病率。

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