Liraglutide for treating type 1 diabetes

Dejgaard Thomas Fremming; Frandsen Christian Seerup; Holst Jens Juul; Madsbad Sten

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Liraglutide for treating type 1 diabetes

机译：利拉鲁肽治疗1型糖尿病

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Introduction: Many persons with type 1 diabetes do not achieve glycemic targets, why new treatments, complementary to insulin, are of interest. Liraglutide, a long-acting glucagon-like peptide-1 receptor agonist could be a potential pharmacological supplement to insulin. This review discusses the mechanism of actions, efficacy and safety of liraglutide as add-on to insulin in persons with type 1 diabetes.

机译：简介：许多1型糖尿病患者均未达到血糖目标，因此为什么要关注与胰岛素互补的新疗法。长效胰高血糖素样肽1受体激动剂利拉鲁肽可能是胰岛素的潜在药理补品。这篇综述讨论了利拉鲁肽作为1型糖尿病患者胰岛素补充剂的作用机制，疗效和安全性。

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《Expert opinion on biological therapy》 |2016年第4期|共12页
作者
Dejgaard Thomas Fremming; Frandsen Christian Seerup; Holst Jens Juul; Madsbad Sten;
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正文语种 eng
中图分类治疗学;
关键词
Type 1 diabetes; liraglutide; HbA1c; body weight; hypoglycaemia; GLP-1 receptor agonist; glucagon-like peptide-1;

机译：1型糖尿病;利拉鲁肽;HbA1c;体重;低血糖;GLP-1受体激动剂;胰高血糖素样肽-1;

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1. Liraglutide effect and action in diabetes-In (LEAD-In): A prospective observational study assessing safety and effectiveness of liraglutide in patients with type 2 diabetes mellitus treated under routine clinical practice conditions in India [J] . Subhash Kumar Wangnoo, Surender Kumar, Arpandev Bhattacharyya, Indian Journal of Endocrinology and Metabolism . 2016,第6期

机译：利拉鲁肽在糖尿病患者中的作用和作用（LEAD-In）：一项前瞻性观察性研究，评估利拉鲁肽在印度常规临床实践条件下治疗的2型糖尿病患者中的安全性和有效性
2. Design and methods of a randomised double-blind trial of adding liraglutide to control HbA1c in patients with type 2 diabetes with impaired glycaemic control treated with multiple daily insulin injections (MDI-Liraglutide trial) [J] . Lind Marcus, Hirsch Irl B., Tuomilehto Jaakko, Primary care diabetes . 2015,第1期

机译：在每天两次胰岛素注射治疗的血糖控制受损的2型糖尿病患者中，加入利拉鲁肽控制HbA1c的随机双盲试验的设计和方法（MDI-利拉鲁肽试验）
3. HEMOGLOBIN A1C (A1C) REDUCTION AND DIABETES-RELATED HEALTH CARE COSTS AMONG TYPE 2 DIABETES (T2DM) PATIENTS TREATED WITH LIRAGLUTIDE OR EXENATIDE: A RETROSPECTIVE CLAIMS DATABASE ANALYSIS [J] . Mocarski M., Tian Y., Buysman E. K., Value in health: the journal of the International Society for Pharmacoeconomics and Outcomes Research . 2016,第7期

机译：利拉糖肽或艾司他汀治疗的2型糖尿病（T2DM）患者中的血红蛋白A1C（A1C）降低和与糖尿病相关的健康护理费用：回顾性索赔数据库分析
4. Clinical and metabolic parameters associated with time in ranges and glucose variability in patients with type 2 diabetes treated with insulin [C] . Julia F. Semenova, Maksim V. Dashkin Conference on Cognitive Sciences, Genomics and Bioinformatics . 2020

机译：胰岛素治疗的2型糖尿病患者的临床和代谢参数与时间范围和葡萄糖变异性相关
5. Incidence of hypoglycemia and associated costs in Type 1and Type 2 diabetes patients treated with insulin analogs vs. human insulin: A retrospective cohort study. [D] . Shah, Hiren P. 2014

机译：使用胰岛素类似物与人胰岛素治疗的1型和2型糖尿病患者的低血糖发生率和相关费用：一项回顾性队列研究。
6. Effect of liraglutide on anthropometric measurements sagittal abdominal diameter and adiponectin levels in people with type 2 diabetes treated with multiple daily insulin injections: evaluations from a randomized trial (MDI‐liraglutide study 5) [O] . S. S. Ahmadi, K. Filipsson, H. Dimenäs, 2019

机译：利拉鲁肽对每天多次胰岛素注射治疗的2型糖尿病患者的人体测量学测量矢状腹径和脂联素水平的影响：一项随机试验的评估（MDI-利拉鲁肽研究5）
7. Liraglutide effect and action in diabetes-In (LEAD-In): A prospective observational study assessing safety and effectiveness of liraglutide in patients with type 2 diabetes mellitus treated under routine clinical practice conditions in India [O] . Subhash Kumar Wangnoo, Surender Kumar, Arpandev Bhattacharyya, 2016

机译：利拉鲁肽在糖尿病中的作用和作用-LE（LEaD-In）：一项前瞻性观察性研究，评估利拉鲁肽在印度常规临床实践条件下治疗的2型糖尿病患者的安全性和有效性

Liraglutide for treating type 1 diabetes

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