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首页> 外文期刊>Expert opinion on biological therapy >Overview of stem cell therapy for Crohn's disease.
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Overview of stem cell therapy for Crohn's disease.

机译：克罗恩病干细胞疗法概述。

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摘要

BACKGROUND: Crohn's disease (CD) therapy is rapidly evolving. Recent and ongoing clinical trials using immunologically active stem cells (SC) for the treatment of CD demonstrate the potential for this novel therapy to induce complete and long-lasting remission of symptoms in settings where 'standard' therapies have been unsuccessful. OBJECTIVE/METHODS: This review of SC, including mesenchymal stem cell (MSC) therapy for CD discusses how the immunological effects of MSC may correct some of the pathophysiological defects underpinning CD, and examines the latest clinical trial data providing evidence of their efficacy in the treatment of Crohn's disease. RESULTS/CONCLUSIONS: Given the beneficial effects on mucosal healing seen in animal models of inflammation and results from early clinical trials, MSC may serve as a candidate therapy for patients who have failed to respond to biological therapy.
机译：背景：克罗恩病（CD）治疗正在迅速发展。使用免疫活性干细胞（SC）治疗CD的最新和正在进行的临床试验证明，这种新疗法在“标准”疗法未成功的环境中具有诱导症状完全和持久缓解的潜力。目的/方法：这篇关于SC的综述，包括CD的间充质干细胞（MSC）治疗，讨论了MSC的免疫学效应如何纠正CD的某些病理生理缺陷，并检查了最新的临床试验数据，提供了其在CD中的疗效证据。克罗恩病的治疗。结果/结论：鉴于炎症动物模型对粘膜愈合的有益作用以及早期临床试验的结果，MSC可以作为对生物疗法无效的患者的候选疗法。

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