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首页> 外文期刊>Expert opinion on biological therapy >Thymic reticulo-epithelial cells: key cells of neuroendocrine regulation.
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Thymic reticulo-epithelial cells: key cells of neuroendocrine regulation.

机译：胸腺网状上皮细胞：神经内分泌调节的关键细胞。

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The reticulo-epithelial (RE) cellular network of the thymic stromal cellular microenvironment plays a vital role in neuroendocrine regulation and lymphoid cell homing and development. Transmission electronmicroscopic observations have confirmed that there are four functional subtypes of medullar RE cells: undifferentiated; squamous; villous; and cystic. Immunocytochemical observations have shown that the secreted thymic hormones, thymosin alpha1 and thymopoietin (and its short form, thymopentin or TP5), are both produced by RE cells. Thymic RE cells also produce numerous cytokines, including IL-1 and -6, G-CSF, macrophage-CSF and GM-CSF that likely are important during the various stages of thymocyte activation and differentiation. The coexistence of pituitary hormone and neuropeptide secretion, such as growth hormone, prolactin, adrenocorticotopic hormone and thyroid-stimulating hormone, among many others, and the production of a number of interleukins and growth factors, as well as the expression of receptors for all, by the same RE cell, is an unique molecular biological phenomenon. The thymic RE cell network represents an important cellular and humoral microenvironment in the neuroendocrine homeopathic regulatory mechanisms of the multicellular organism.
机译：胸腺基质细胞微环境的网状上皮（RE）细胞网络在神经内分泌调节以及淋巴样细胞的归巢和发育中起着至关重要的作用。透射电镜观察已经证实，髓质RE细胞有四种功能亚型：未分化的;未分化的;未分化的。鳞状的绒毛和囊性的。免疫细胞化学观察表明，分泌的胸腺激素胸腺素α1和胸腺生成素（及其简称，胸腺五肽或TP5）均由RE细胞产生。胸腺RE细胞还产生多种细胞因子，包括IL-1和-6，G-CSF，巨噬细胞CSF和GM-CSF，它们可能在胸腺细胞激活和分化的各个阶段都很重要。垂体激素和神经肽分泌（例如生长激素，催乳激素，促肾上腺皮质激素和促甲状腺激素）共存，以及许多白介素和生长因子的产生以及所有受体的表达，由同一个RE细胞，是一种独特的分子生物学现象。胸腺RE细胞网络在多细胞生物的神经内分泌顺势调节机制中代表着重要的细胞和体液微环境。

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