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首页> 外文期刊>Expert opinion on biological therapy >The wound-healing and antioxidant effects of adipose-derived stem cells.
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The wound-healing and antioxidant effects of adipose-derived stem cells.

机译：脂肪干细胞的伤口愈合和抗氧化作用。

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摘要

BACKGROUND: The aim of tissue engineering is to repair and regenerate damaged organs using a combination of cells, biomaterials and growth factors. Mesenchymal stem cells within the stromal-vascular fraction of subcutaneous adipose tissue, that is adipose-derived stem cells (ADSCs) have been used in skin repair with satisfactory results. The production and secretion of growth factors has been reported to be an essential function of ADSCs, and diverse regenerative effects of ADSCs in the skin have been demonstrated. OBJECTIVE: Recent research developments concerning the wound-healing and antioxidant effects of ADSCs are briefly described. METHODS: Various experimental results regarding the wound-healing and antioxidant effect of ADSCs are introduced, and the mechanisms and identification of active proteins involved in these function are further discussed. RESULTS/CONCLUSION: Evidence of ADSC differentiation of skin has not been reported in vivo, but ADSCs accelerate wound-healing and exhibit antioxidant effects under various conditions. The wound-healing and antioxidant effects of ADSCs are mainly mediated by the activation of dermal fibroblasts and keratinocytes via the paracrine mechanism. Since ADSCs are easily obtained in large quantities and have an advantage over other stem cell sources, ADSCs and their secretory factors show promise for use in skin repair and regeneration.
机译：背景：组织工程的目的是利用细胞，生物材料和生长因子的组合来修复和再生受损的器官。皮下脂肪组织的基质-血管部分内的间充质干细胞，即脂肪来源的干细胞（ADSCs）已用于皮肤修复，取得了令人满意的结果。据报道，生长因子的产生和分泌是ADSCs的基本功能，并且已经证明了ADSCs在皮肤中的多种再生作用。目的：简要介绍有关ADSCs的伤口愈合和抗氧化作用的最新研究进展。方法：介绍了有关ADSCs的伤口愈合和抗氧化作用的各种实验结果，并进一步讨论了涉及这些功能的活性蛋白的机理和鉴定。结果/结论：尚无体内ADSC皮肤分化的证据，但ADSC在各种条件下均能促进伤口愈合并表现出抗氧化作用。 ADSCs的伤口愈合和抗氧化作用主要是通过旁分泌机制激活真皮成纤维细胞和角质形成细胞介导的。由于容易获得大量的ADSC，并且具有优于其他干细胞来源的优势，因此ADSC及其分泌因子显示出可用于皮肤修复和再生的前景。

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