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首页> 外文期刊>Expert opinion on biological therapy >Fate and manipulations of endogenous neural stem cells following brain ischemia.
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Fate and manipulations of endogenous neural stem cells following brain ischemia.

机译：脑缺血后内源性神经干细胞的命运和操纵。

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Stem cells have been proposed as a new form of cell-based therapy in a variety of disorders, including acute and degenerative brain diseases. Endogenous neural stem cells (eNSCs) have been identified in the central nervous system where they reside largely in the subventricular zone and in the subgranular zone of the hippocampus. eNSCs are capable of self-renewal and differentiation into functional glia and neurons throughout life. However, spontaneous brain regeneration does not suffice to induce significant behavioral improvement in acute or chronic brain injury. Nevertheless, eNSCs responses can be considerably increased by tweaking the pathways governing cell proliferation, migration and differentiation. Contemporary evidence now suggests that such perturbations may lead to better functional outcome after brain injury.
机译：已经提出了干细胞作为基于细胞的治疗的新形式，用于多种疾病，包括急性和变性脑疾病。内源性神经干细胞（eNSC）已在中枢神经系统中被发现，它们主要位于海马的脑室下区和颗粒下区。 eNSC能够在整个生命中自我更新并分化为功能性胶质细胞和神经元。但是，自发性大脑再生不足以在急性或慢性脑损伤中引起明显的行为改善。尽管如此，通过调节控制细胞增殖，迁移和分化的途径，可以大大提高eNSCs的反应。现在的现代证据表明，这种扰动可能导致脑损伤后更好的功能预后。

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