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首页> 外文期刊>Expert opinion on biological therapy >Strategies to improve non-viral vectors--potential applications in clinical transplantation.
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Strategies to improve non-viral vectors--potential applications in clinical transplantation.

机译：改善非病毒载体的策略-在临床移植中的潜在应用。

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Prevention of acute rejection has been well controlled with immunosuppressive drugs. However, the long-term control of rejection is less satisfactory and the side effects of chronic usage of these drugs are far from acceptable. Thus, more imaginative options for therapy need to be explored. Gene therapy has potential promise in preserving allografts, preventing rejection and inducing tolerance. Despite this initial promise in many animal models, the translation of gene therapy to the clinical arena has been slow. This may be related in part to the deficiencies in vector development. Existing viral vectors are efficient at transducing allografts, but they induce inflammatory and pathogenic effects. Although the alternative non-viral systems are relatively innocuous, they are less efficient at gene delivery. This review systematically analyses the limitations of non-viral vector technology and the strategies that have been developed to overcome these limitations. Future development of non-viral vectors may have potential application in clinical transplantation.
机译：免疫抑制药物已很好地控制了急性排斥反应的预防。但是，长期控制排斥反应的效果较差，长期使用这些药物的副作用远不能令人满意。因此，需要探索更具想象力的治疗选择。基因疗法在保存同种异体移植物，防止排斥和诱导耐受性方面具有潜在的前景。尽管在许多动物模型中都有这一最初的希望，但基因治疗向临床领域的翻译一直很缓慢。这可能部分与载体开发的缺陷有关。现有的病毒载体在转导同种异体移植物方面是有效的，但是它们诱导炎症和致病作用。尽管替代的非病毒系统相对无害，但它们在基因传递方面的效率较低。这篇综述系统地分析了非病毒载体技术的局限性以及为克服这些局限性而开发的策略。非病毒载体的未来发展可能在临床移植中具有潜在的应用。

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