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首页> 外文期刊>Expert opinion on biological therapy >Humoral immunotherapy of multiple myeloma: perspectives and perplexities.
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Humoral immunotherapy of multiple myeloma: perspectives and perplexities.

机译：多发性骨髓瘤的体液免疫治疗：观点和困惑。

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摘要

IMPORTANCE OF THE FIELD: Multiple myeloma (MM) is a hematological malignancy still remaining incurable despite the various therapies available, mainly because of the high fraction of refractory/relapsing cases. Therefore, the development of novel therapeutic approaches is urgently needed to overcome conventional treatment resistance. AREAS COVERED IN THIS REVIEW: In the era of targeted therapies, treatments combining a high specificity for neoplastic cells and the capability to interfere with environmental signals should be regarded as the weapons of choice. Monoclonal antibody (mAb)-based humoral immunotherapy could satisfy both these requirements when applied to MM. Indeed, many of the molecules expressed on MM cells, such as CD38, CD40, CD49d, CD138 and CD162 are involved in the adhesive dynamics regulating the crosstalk between MM and the BM-microenvironment. WHAT THE READER WILL GAIN: In this study we review those MM-associated molecules that have shown promising antitumor effects as targets of specific mAbs in preclinical settings, thus deserving to be considered for clinical investigation. TAKE HOME MESSAGE: mAbs directed against MM-associated adhesion markers should be taken into account in clinical practice, since they could possibly represent the best available combination of tumor cytotoxicity, environmental signal deprivation and immune system redirection.
机译：领域的重要性：尽管有多种可用的治疗方法，但多发性骨髓瘤（MM）是一种血液学恶性肿瘤，仍然是无法治愈的，主要是由于难治/复发病例的高比例。因此，迫切需要开发新的治疗方法来克服常规的治疗抗性。本综述涵盖的领域：在靶向治疗的时代，结合肿瘤细胞高特异性和干扰环境信号能力的治疗应被视为首选武器。当应用于MM时，基于单克隆抗体（mAb）的体液免疫疗法可以满足这两个要求。实际上，在MM细胞上表达的许多分子，例如CD38，CD40，CD49d，CD138和CD162均参与调节MM与BM微环境之间的串扰的黏附动力学。读者将获得什么：在这项研究中，我们审查那些在临床前环境中显示出有希望的抗肿瘤作用作为特定mAb靶标的MM相关分子，因此值得考虑用于临床研究。寄语：临床实践中应考虑针对MM相关粘附标记的单克隆抗体，因为它们可能代表了肿瘤细胞毒性，环境信号剥夺和免疫系统重定向的最佳组合。

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