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Decoy activity through microRNAs: the therapeutic implications.

机译：通过microRNA诱骗的活动：治疗意义。

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INTRODUCTION: microRNAs (miRNAs), small noncoding RNAs, are deregulated in several diseases including cancer. miRNAs regulate gene expression at a posttranscriptional level by binding to 5'UTR, coding regions or 3'UTR of messenger RNAs (mRNA), inhibiting mRNA translation or causing mRNA degradation. The same miRNA can have multiple mRNA targets, and the same mRNA can be regulated by various miRNAs. AREAS COVERED: Recently, seminal contributions by several groups have implicated miRNAs as components of an RNA-RNA language that involves cross-talk between competing endogenous RNAs through a decoy mechanism. We review the studies that described miRNAs as players in a biological decoy activity. miRNAs can either be trapped by competing endogenous RNAs or interact with proteins that have binding sites for mRNAs. EXPERT OPINION: The miRNA decoy functions have implications for the design of therapeutic approaches in human diseases, including specific ways to overcome resistance to drug therapy and future miRNA-based clinical trials design.
机译：简介：microRNA（miRNA）是小的非编码RNA，在包括癌症在内的多种疾病中均被放松调节。 miRNA通过与信使RNA（mRNA）的5'UTR，编码区或3'UTR结合，在转录后水平上调节基因表达，抑制mRNA的翻译或引起mRNA的降解。相同的miRNA可以具有多个mRNA靶标，并且相同的mRNA可以由多种miRNA调控。覆盖的领域：最近，几个小组的开创性研究表明，miRNA是RNA-RNA语言的组成部分，它通过诱饵机制涉及竞争内源性RNA之间的串扰。我们审查了描述miRNA为生物诱饵活动参与者的研究。 miRNA可以被竞争性内源RNA捕获或与具有mRNA结合位点的蛋白质相互作用。专家意见：miRNA诱饵功能对人类疾病治疗方法的设计具有影响，包括克服药物治疗耐药性的特定方法以及未来基于miRNA的临床试验设计。

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