Monoclonal antibodies for the treatment of non-haematological tumours: update of an expanding scenario

Bronte Giuseppe; Sortino Giovanni; Passiglia Francesco; Rizzo Sergio; Lo Vullo Francesca; Galvano Antonio; Bazan Viviana; Rolfo Christian; Russo Antonio

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Monoclonal antibodies for the treatment of non-haematological tumours: update of an expanding scenario

机译：用于治疗非血液肿瘤的单克隆抗体：不断扩大的应用场景的更新

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Introduction: The identification of cell membrane-bound molecules with a relevant role in cancer cell survival prompted the development of moAbs to block the related pathways. In the last few years, the number of approved moAbs for cancer treatment has constantly increased. Many of these drugs significantly improved the survival outcomes in patients with solid tumours.

机译：简介：对在癌细胞存活中具有重要作用的细胞膜结合分子的鉴定促使moAb的发展，从而阻断了相关途径。在过去的几年中，批准用于癌症治疗的单克隆抗体的数量一直在增加。其中许多药物显着改善了实体瘤患者的生存结果。

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《Expert opinion on biological therapy》 |2015年第1期|共15页
作者
Bronte Giuseppe; Sortino Giovanni; Passiglia Francesco; Rizzo Sergio; Lo Vullo Francesca; Galvano Antonio; Bazan Viviana; Rolfo Christian; Russo Antonio;
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正文语种 eng
中图分类治疗学;
关键词
cancer; cancer antigen; cytotoxic T-lymphocyte antigen 4; EGFR; HER2; immunotherapy; moAbs; receptor activator of nuclear factor kappa B ligand; VEGF;

机译：癌症;癌抗原;细胞毒性T淋巴细胞抗原4;EGFR;HER2;免疫治疗;moAbs;核因子κB配体的受体激活剂;VEGF;

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1. Monoclonal antibodies for the treatment of non-haematological tumours: update of an expanding scenario [J] . Bronte Giuseppe, Sortino Giovanni, Passiglia Francesco, Expert opinion on biological therapy . 2015,第1期

机译：用于治疗非血液肿瘤的单克隆抗体：不断扩大的应用场景的更新
2. Unmasking of a primary desmoplastic melanoma tumour in the course of treatment of a metastatic disease with anti‐ PD PD ‐1 monoclonal antibody [J] . Richtig G., Ramelyte E., Koch L., Journal of the European Academy of Dermatology and Venereology: JEADV . 2019,第10期

机译：在治疗抗PD -1单克隆抗体的治疗过程中揭示初级去制剂黑素瘤肿瘤
3. Suppression of tumour metastasis in a murine osteosarcoma model with anti-CD25 monoclonal antibody treatment. [J] . Kozawa E, Sugiura H, Wasa J, Anticancer Research: International Journal of Cancer Research and Treatment . 2010,第12期

机译：用抗CD25单克隆抗体治疗抑制鼠骨肉瘤模型中的肿瘤转移。
4. Efficient Acquisition of Antigen-Specific Human Monoclonal Antibody by Using Peripheral Blood Mononuclear Cells Immunized In Vitro Efficient Cloning of Human Monoclonal Antibody Gene [C] . Shinei Matsumoto, Makiko Yamashita, Yoshinori Katakura, Annual Meeting of the Japanese Association for Animal Cell Technology . 2009

机译：通过使用在体外克隆人单克隆抗体基因的体外克隆的外周血单核细胞高效采集抗原特异性人单克隆抗体
5. Characterization of Anti-Ricin Monoclonal Antibodies and the Construction of a Chimeric Murine-Human IgG2/K Anti-Ricin Monoclonal Antibody [D] . Vendramelli, Robert Matthew 2011

机译：抗蓖麻毒蛋白单克隆抗体的表征和鼠/人IgG2 / K嵌合抗蓖麻毒蛋白单克隆抗体的构建
6. Update on D2E7: a fully human anti-tumour necrosis factor α monoclonal antibody [O] . J. Kempeni 2000

机译：D2E7的最新进展：完全的人类抗肿瘤坏死因子α单克隆抗体
7. Monoclonal antibodies for the treatment of non-haematological tumours: Update of an expanding scenario [O] . Bronte G., Sortino G., Passiglia F., 2015

机译：用于治疗非血液肿瘤的单克隆抗体：不断扩大的情况的更新

Monoclonal antibodies for the treatment of non-haematological tumours: update of an expanding scenario

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