Development of a novel AIDS vaccine: the HIV-1 transactivator of transcription protein vaccine

Cafaro Aurelio; Tripiciano Antonella; Sgadari Cecilia; Bellino Stefania; Picconi Orietta; Longo Olimpia; Francavilla Vittorio; Butto Stefano; Titti Fausto; Monini Paolo; Ensoli Fabrizio; Ensoli Barbara

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Development of a novel AIDS vaccine: the HIV-1 transactivator of transcription protein vaccine

机译：新型艾滋病疫苗的开发：转录蛋白疫苗的HIV-1反式激活剂

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Introduction: Classical approaches aimed at targeting the HIV-1 envelope as well as other structural viral proteins have largely failed. The HIV-1 transactivator of transcription (Tat) is a key HIV virulence factor, which plays pivotal roles in virus gene expression, replication, transmission and disease progression. Notably, anti-Tat Abs are uncommon in natural infection and, when present, correlate with the asymptomatic state and lead to lower or no disease progression. Hence, targeting Tat represents a pathogenesis-driven intervention.

机译：简介：旨在靶向HIV-1包膜以及其他结构性病毒蛋白的经典方法在很大程度上失败了。 HIV-1转录反式激活因子（Tat）是关键的HIV毒力因子，它在病毒基因表达，复制，传播和疾病进展中起关键作用。值得注意的是，抗Tat抗体在自然感染中并不常见，如果存在，则与无症状状态相关，导致疾病进展较低或无进展。因此，靶向Tat代表了发病机制驱动的干预。

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《Expert opinion on biological therapy》 |2015年第s1期|共17页
作者
Cafaro Aurelio; Tripiciano Antonella; Sgadari Cecilia; Bellino Stefania; Picconi Orietta; Longo Olimpia; Francavilla Vittorio; Butto Stefano; Titti Fausto; Monini Paolo; Ensoli Fabrizio; Ensoli Barbara;
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正文语种 eng
中图分类治疗学;
关键词
HAART intensification; HIV-1 eradication; HIV-1 therapeutic vaccine; neutralization Tat;

机译：HAART强化;根除HIV-1;HIV-1治疗性疫苗;中和Tat;

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1. Development of a novel AIDS vaccine: the HIV-1 transactivator of transcription protein vaccine [J] . Cafaro Aurelio, Tripiciano Antonella, Sgadari Cecilia, Expert opinion on biological therapy . 2015,第S1期

机译：新型艾滋病疫苗的开发：转录蛋白疫苗的HIV-1反式激活剂
2. HIV-1 Tat-based vaccines: an overview and perspectives in the field of HIV/AIDS vaccine development. [J] . Caputo A, Gavioli R, Bellino S International reviews of immunology . 2009,第5期

机译：基于HIV-1 Tat的疫苗：HIV / AIDS疫苗开发领域的概述和观点。
3. Defining the objectives of the AIDS vaccine for Asia network: report of the WHO-UNAIDS/Global HIV vaccine enterprise regional consultation on expanding AIDS vaccine research and development capacity in Asia. [J] . Rerks Ngarm S, Pitisuttithum P, Ganguly N, Current opinion in HIV and AIDS . 2010,第5期

机译：定义亚洲艾滋病疫苗网络的目标：关于扩大亚洲艾滋病疫苗研发能力的WHO-UNAIDS /全球HIV疫苗企业区域磋商报告。
4. Design of a CD4 miniprotein,powerful inhibitor of HIV-1 infection and potential potential component of an AIDS vaccine [C] . Loic Martin, Francois Stricher, Isabelle Freulon, European Peptide Symposium . 2002

机译：设计CD4微细蛋白，强大的HIV-1感染抑制剂及艾滋病疫苗的潜在潜在组分
5. HIV-1 Tat protein as a component of a vaccine for AIDS: Natural and vaccine induced humoral immune responses to Tat. [D] . Richardson, Max W. 2003

机译：HIV-1 Tat蛋白作为AIDS疫苗的组成部分：天然和疫苗诱导的针对Tat的体液免疫反应。
6. Antibody to human immunodeficiency virus type 1 (HIV-1) gp160 in mucosal specimens of asymptomatic HIV-1-infected volunteers parenterally immunized with an experimental recombinant HIV-1 IIIB gp160 vaccine. The National Institute of Allergy and Infectious Diseases-sponsored AIDS Vaccine Evaluation Group. [O] . J S Lambert, R Viscidi, M C Walker, 1997

机译：用实验性重组HIV-1 IIIB gp160疫苗进行肠胃外免疫的无症状HIV-1感染志愿者粘膜标本中的人类1型免疫缺陷病毒（HIV-1）gp160抗体。美国过敏和传染病研究所赞助的艾滋病疫苗评估小组。
7. HIV-1 Tat-Based Vaccines: An Overview and Perspectives in the Field of HIV/AIDS Vaccine Development [O] . Antonella Caputo, Riccardo Gavioli, Stefania Bellino, 2014

机译：HIV-1基于Tat的疫苗：HIV / aIDs疫苗开发领域的概述和观点
8. Development of Safe, Effective Vaccines for Dengue Virus Disease by RecombinantBaculovirus. Subtitle: Development of Safe, Effective Vaccines for Dengue Disease Utilizing Viral Envelope and NSI Glycoproteins Expressed by Recombinant Baculovirus [R] . Lai, C. J. 1991

机译：利用重组杆状病毒开发安全有效的登革病毒疫苗。副标题：利用重组杆状病毒表达的病毒包膜和NsI糖蛋白开发安全有效的登革病疫苗

Development of a novel AIDS vaccine: the HIV-1 transactivator of transcription protein vaccine

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