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Why regenerative medicine needs an extracellular matrix

机译：为什么再生医学需要细胞外基质

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Regenerative medicine is now coming of age. Many attempts at cell therapy have failed to show significant efficacy, and the umbrella term 'stem cell therapy' is perceived in some quarters as hype or just expensive and unnecessary medical tourism. Here we present a short editorial in three parts. First, we examine the importance of using a semisynthetic extracellular matrix (ECM) mimetic, or sECM, to deliver and retain therapeutic cells at the site of administration. Second, we describe one approach in which biophysical and biochemical properties are tailored to each tissue type, which we call "design for optimal functionality." Third, we describe an alternative approach to sECM design and implementation, called "design for simplicity," in which a deconstructed, minimalist sECM is employed and biology is allowed to perform the customization in situ. We opine that an sECM, whether minimal or instructive, is an essential contributor to improve the outcomes of cell-based therapies.
机译：再生医学正在走向成熟。细胞疗法的许多尝试均未显示出显着的功效，总括性术语“干细胞疗法”在某些方面被视为炒作或仅仅是昂贵而不必要的医疗旅游。在这里，我们分三部分介绍简短的社论。首先，我们研究了使用半合成的细胞外基质（ECM）模拟物或sECM在给药部位递送和保留治疗性细胞的重要性。其次，我们描述了一种针对每种组织类型定制生物物理和生化特性的方法，我们称其为“最佳功能设计”。第三，我们描述了sECM设计和实现的另一种方法，称为“为简单而设计”，其中采用了经过解构的极简sECM，并允许生物学就地进行定制。我们认为，sECM，无论是最小的还是有启发性的，都是改善基于细胞疗法的结果的重要因素。

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