NK cell subsets and their role in allergy.

Deniz G; Akdis M

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NK cell subsets and their role in allergy.

机译：NK细胞亚群及其在过敏中的作用。

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INTRODUCTION: NK cells represent a distinct lymphocyte population with extensive cytolytic activity and a variety of other functions, including regulation of hemopoiesis, suppressor functions and immunoglobulin production. Recently, reports suggest that NK cells also display potent regulatory functions via secretion of cytokines or cell-contact-dependent mechanisms. Thus NK cells may regulate innate and adaptive immune responses and play a role in immune homeostasis. AREAS COVERED: NK cells play important roles in viral infections, autoimmunity, pregnancy, cancer and bone marrow transplantation. Although the role of NK cells in allergic diseases is poorly described, recent findings suggest their role in allergy. EXPERT OPINION: Recent developments in the study of NK cell subsets have support their role in allergic diseases that contribute to allergen-specific immune suppression, allergen-specific T(H)1 cell generation as well as IgE and other Ig production.

机译：简介：NK细胞代表具有广泛的细胞溶解活性和多种其他功能的独特淋巴细胞群，包括调节造血，抑制功能和免疫球蛋白的产生。最近，有报道表明NK细胞还通过分泌细胞因子或依赖细胞接触的机制显示出强大的调节功能。因此，NK细胞可以调节先天性和适应性免疫反应，并在免疫稳态中发挥作用。覆盖的区域：NK细胞在病毒感染，自身免疫，妊娠，癌症和骨髓移植中起着重要作用。尽管对NK细胞在变应性疾病中的作用的描述很少，但最近的发现表明它们在变态反应中的作用。专家意见：NK细胞亚群研究的最新进展支持了它们在过敏性疾病中的作用，这些疾病有助于过敏原特异性免疫抑制，过敏原特异性T（H）1细胞生成以及IgE和其他Ig产生。

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《Expert opinion on biological therapy》 |2011年第7期|共9页
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Deniz G; Akdis M;
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正文语种 eng
中图分类治疗学;
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1. NK cell subsets and their role in allergy. [J] . Deniz G, Akdis M Expert opinion on biological therapy . 2011,第7期

机译：NK细胞亚群及其在过敏中的作用。
2. Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets [J] . Clancy-Thompson Eleanor, Chen Gui Zhen, Tyler Paul M., The Journal of Immunology: Official Journal of the American Association of Immunologists . 2017,第1期

机译：单克隆不变NKT（Inkt）细胞小鼠揭示了原产地和TCR在Inkt功能子集的发展中的作用
3. Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets [J] . Eleanor Clancy-Thompson, Gui Zhen Chen, Paul M. Tyler, The journal of immunology . 2017,第1期

机译：单克隆不变NKT（iNKT）细胞小鼠揭示了iNKT功能亚集发育过程中起源组织和TCR的作用。
4. Introduction of NKT cell, a novel immunoregulatory subset and in vitro studies involving activated NKT cell [C] . Huazhong Lu, Deming Sun, Feng Gao 11th Regional Western Pacific Congress of International Society of Blood Transfusion Nov, 2001 Shanghai . 2001

机译：NKT细胞（一种新的免疫调节子集）的引入以及涉及活化NKT细胞的体外研究
5. Identification of a major subset of murine NK cells: Generation of a monoclonal antibody detecting the LGL-1 antigen and functional properties of LGL-1(+) and LGL-1(-) NK cells. [D] . Mason, Llewellyn Hoffman. 1992

机译：鉴定鼠类NK细胞的主要子集：产生检测LGL-1抗原和LGL-1（+）和LGL-1（-）NK细胞功能特性的单克隆抗体。
6. Monoclonal iNKT cell mice reveal a role for both tissue of origin and the TCR in development of iNKT functional subsets [O] . Eleanor Clancy-Thompson, Gui Zhen Chen, Paul M. Tyler, -1

机译：单克隆iNKT细胞小鼠揭示了iNKT功能亚型发育过程中起源组织和TCR的作用
7. Analysis of T and NK cell subsets in the Sicilian population from young to supercentenarian: The role of age and gender [O] . Mattia Emanuela Ligotti, Anna Aiello, Giulia Accardi, 2021

机译：从年轻到超中心的西西里人群T和NK细胞群分析：年龄和性别的作用
8. Immunoultrastructural Studies of Human NK (Natural Killer) Cells. 1. Ultracytochemistry and Comparison with T Cell Subsets [R] . Kang, Y. H., Carl, M., Grimley, P. M., 1987

机译：人NK（自然杀伤）细胞的免疫结构研究。 1.超微细胞化学与T细胞亚群的比较

NK cell subsets and their role in allergy.

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