Dual effect of Thymosin alpha 1 on human monocyte-derived dendritic cell in vitro stimulated with viral and bacterial toll-like receptor agonists

Giacomini Elena; Severa Martina; Cruciani Melania; Etna Marilena Paola; Rizzo Fabiana; Pardini Manuela; Scagnolari Carolina; Garaci Enrico; Coccia Eliana Marina

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Dual effect of Thymosin alpha 1 on human monocyte-derived dendritic cell in vitro stimulated with viral and bacterial toll-like receptor agonists

机译：胸腺素α1对人单核细胞衍生的树突状细胞在体外被病毒和细菌性Toll样受体激动剂刺激的双重作用

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Objectives: Thymosin a 1 (T alpha 1) recently gained interest as immune adjuvant for vaccines because of its ability to modulate the T-cell/dendritic cell (DC) axis and to improve antibody production. The objective of this study was to determine whether T alpha 1 would address in vitro the response of human primary nnonocyte-derived DC, crucial regulators of vaccine-induced immunity, upon exposure to different toll-like receptor (TLR) agonists or infection with viruses or bacteria.

机译：目标：胸腺素1（T alpha 1）最近作为疫苗的免疫佐剂而受到关注，因为它具有调节T细胞/树突状细胞（DC）轴并改善抗体产生的能力。这项研究的目的是确定在暴露于不同的Toll样受体（TLR）激动剂或感染病毒后，T alpha 1是否能在体外解决人类原发性非细胞衍生DC的反应，疫苗诱导的免疫的关键调节剂或细菌。

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来源
《Expert opinion on biological therapy》 |2015年第s1期|共12页
作者
Giacomini Elena; Severa Martina; Cruciani Melania; Etna Marilena Paola; Rizzo Fabiana; Pardini Manuela; Scagnolari Carolina; Garaci Enrico; Coccia Eliana Marina;
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正文语种 eng
中图分类治疗学;
关键词
dendritic cell; human; Thymosin alpha 1; toll-like receptor;

机译：树突状细胞;人;胸腺素α1;toll样受体;

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1. Dual effect of Thymosin alpha 1 on human monocyte-derived dendritic cell in vitro stimulated with viral and bacterial toll-like receptor agonists [J] . Giacomini Elena, Severa Martina, Cruciani Melania, Expert opinion on biological therapy . 2015,第S1期

机译：胸腺素α1对人单核细胞衍生的树突状细胞在体外被病毒和细菌性Toll样受体激动剂刺激的双重作用
2. NF546 (4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-car bonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid) tetrasodium salt) is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells. [J] . Meis S, Hamacher A, Hongwiset The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2010,第1期

机译：NF546（4,4'-（羰基双（亚氨基-3,1-亚苯基-羰基亚氨基-3,1-（4-甲基亚苯基）-苯甲醛））-双（1,3-二甲苯-α，α'- （二膦酸四钠盐）是一种非核苷酸P2Y11激动剂，可刺激白细胞介素8从人单核细胞衍生的树突状细胞中释放。
3. Combined use of toll-like receptor agonists and prostaglandin E(2) in the FastDC model: rapid generation of human monocyte-derived dendritic cells capable of migration and IL-12p70 production. [J] . Dauer M, Lam V, Arnold H, Journal of Immunological Methods . 2008,第2期

机译：在FastDC模型中结合使用toll样受体激动剂和前列腺素E（2）：快速生成人单核细胞衍生的树突状细胞，能够迁移并产生IL-12p70。
4. Dendritic cell targeted nano-vaccine delivery system engineered from a plant polymer based Toll-Like Receptor-4 agonist Inulin Acetate [C] . Siddharth S. Kesharwani, Mrigendra K.S. Rajput, Sunny Kumar, Society for Biomaterials annual meeting and exposition . 2017

机译：树突状细胞靶向纳米疫苗递送系统，由基于植物聚合物的Toll-Like Receptor-4激动剂菊糖乙酸酯设计而成
5. The effects of toll-like receptor ligand-activated dendritic cells on human CD4+ T cell responses. [D] . Benwell, Risa Kitawaki. 2008

机译：Toll样受体配体激活的树突状细胞对人CD4 + T细胞反应的影响。
6. Whole blood stimulation with Toll-like receptor (TLR)-7/8 and TLR-9 agonists induces interleukin-12p40 expression in plasmacytoid dendritic cells in rhesus macaques but not in humans [O] . G Koopman, N Beenhakker, S Burm, 2013

机译：用Toll样受体（TLR）-7/8和TLR-9激动剂进行全血刺激可在猕猴的浆细胞样树突状细胞中诱导白细胞介素12p40表达但在人类中却不
7. Dual effect of Thymosin α 1 on human monocyte-derived dendritic cellin vitrostimulated with viral and bacterial toll-like receptor agonists [O] . Elena Giacomini, Martina Severa, Melania Cruciani, 2015

机译：胸腺素α1对人单核细胞衍生的树突状纤维菌素的双重作用，病毒和细菌性收缩受体激动剂

Dual effect of Thymosin alpha 1 on human monocyte-derived dendritic cell in vitro stimulated with viral and bacterial toll-like receptor agonists

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