Enhancing dendritic cell-based vaccination for highly aggressive glioblastoma

Batich Kristen A.; Swartz Adam M.; Sampson John H.

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Enhancing dendritic cell-based vaccination for highly aggressive glioblastoma

机译：增强针对高度侵袭性胶质母细胞瘤的基于树突细胞的疫苗接种

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Introduction: Patients with primary glioblastoma (GBM) have a dismal prognosis despite standard therapy, which can induce potentially deleterious side effects. Arming the immune system is an alternative therapeutic approach, as its cellular effectors and inherent capacity for memory can be utilized to specifically target invasive tumor cells, while sparing collateral damage to otherwise healthy brain parenchyma.

机译：简介：尽管采用标准疗法，原发性胶质母细胞瘤（GBM）患者的预后却令人沮丧，这可能会引起潜在的有害副作用。装备免疫系统是另一种治疗方法，因为它的细胞效应器和固有的记忆力可用于特异性靶向侵袭性肿瘤细胞，同时避免对健康的脑实质产生附带损害。

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《Expert opinion on biological therapy》 |2015年第1期|共16页
作者
Batich Kristen A.; Swartz Adam M.; Sampson John H.;
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正文语种 eng
中图分类治疗学;
关键词
antigen escape; dendritic cell; EGFR variant III; glioblastoma; immunotherapy; tumor-specific antigen;

机译：抗原逃逸;树突状细胞;EGFR变体III;胶质母细胞瘤;免疫治疗;肿瘤特异性抗原;

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1. Enhancing dendritic cell-based vaccination for highly aggressive glioblastoma [J] . Batich Kristen A., Swartz Adam M., Sampson John H. Expert opinion on biological therapy . 2015,第1期

机译：增强针对高度侵袭性胶质母细胞瘤的基于树突细胞的疫苗接种
2. Predicting combinations of immunomodulators to enhance dendritic cell-based vaccination based on a hybrid experimental and computational platform [J] . Rita Ahmed, Isaac Crespo, Sandra Tuyaerts, Computational and Structural Biotechnology Journal . 2020,第1期

机译：基于混合实验和计算平台预测免疫调节剂组合以增强树突式细胞的疫苗接种
3. Inhibition of HIF-1 alpha enhances anti-tumor effects of dendritic cell-based vaccination in a mouse model of breast cancer [J] . Kheshtchin Nasim, Arab Samaneh, Ajami Maryam, Cancer immunology, immunotherapy : . 2016,第10期

机译：HIF-1α的抑制作用增强乳腺癌小鼠模型中基于树突细胞的疫苗接种的抗肿瘤作用
4. Dendritic cell vaccination for glioblastoma multiforme: Clinical experience and future directions [C] . Dejaegher Joost, Solie Lien, De Vleeschouwer Steven, Proceedings of the 2014 6th International Advanced Research Workshop on In Silico Oncology and Cancer Investigation - The TUMOR Project Workshop . 2014

机译：胶质母细胞瘤的树突状细胞疫苗接种：临床经验和未来方向
5. Mechanisms underlying tumor resistance to CD8+ T cell-based therapeutic vaccination. [D] . Huang, Yujun. 2006

机译：肿瘤对基于CD8 + T细胞的治疗性疫苗产生抗性的机制。
6. IMMU-09. COMBINATION IMMUNE TREATMENT OF A HIGHLY AGGRESSIVE ORTHOTOPIC MURINE GLIOBLASTOMA WITH CHECKPOINT BLOCKADE AND MULTI-VALENT NEOANTIGEN VACCINATION [O] . Connor Liu, Maximilian Schaettler, Jay Bowman-Kirigin, 2019

机译：IMMU-09。用检查点封闭和多价新尼尼虫疫苗接种的高侵袭性原位鼠胶质细胞瘤的组合免疫处理
7. Predicting combinations of immunomodulators to enhance dendritic cell-based vaccination based on a hybrid experimental and computational platform [O] . Rita Ahmed, Isaac Crespo, Sandra Tuyaerts, 2020

机译：基于混合实验和计算平台预测免疫调节剂组合以增强树突式细胞的疫苗接种
8. Inhibition of the Protein Tyrosine Phosphatase, SHP-1, in Dendritic Cells to Enhance their Efficacy as Cell-Based Prostate Cancer Vaccines [R] . Levitt, J. M. 2009

机译：在树突状细胞中抑制蛋白酪氨酸磷酸酶sHp-1以增强其作为基于细胞的前列腺癌疫苗的功效

Enhancing dendritic cell-based vaccination for highly aggressive glioblastoma

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