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首页> 外文期刊>Expert opinion on biological therapy >Living cardiac patch: the elixir for cardiac regeneration.
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Living cardiac patch: the elixir for cardiac regeneration.

机译：活体心脏补丁：用于心脏再生的the剂。

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INTRODUCTION: A thorough understanding of the cellular and muscle fiber orientation in left ventricular cardiac tissue is of paramount importance for the generation of artificial cardiac patches to treat the ischemic myocardium. The major challenge faced during cardiac patch engineering is to choose a perfect combination of three entities; cells, scaffolds and signaling molecules comprising the tissue engineering triad for repair and regeneration. AREAS COVERED: This review provides an overview of various scaffold materials, their mechanical properties and fabrication methods utilized in cardiac patch engineering. Stem cell therapies in clinical trials and the commercially available cardiac patch materials were summarized in an attempt to provide a recent perspective in the treatment of heart failure. Various tissue engineering strategies employed thus far to construct viable thick cardiac patches is schematically illustrated. EXPERT OPINION: Though many strategies have been proposed for fabrication of various cardiac scaffold materials, the stage and severity of the disease condition demands the incorporation of additional cues in a suitable scaffold material. The scaffold may be nanofibrous patch, hydrogel or custom designed films. Integration of stem cells and biomolecular cues along with the scaffold may provide the right microenvironment for the repair of unhealthy left ventricular tissue as well as promote its regeneration.
机译：简介：彻底了解左心室心脏组织中细胞和肌肉纤维的取向对于产生用于治疗缺血性心肌的人造心脏斑块至关重要。在心脏贴片工程中面临的主要挑战是选择三个实体的完美组合。包括组织工程三联体的细胞，支架和信号传导分子，用于修复和再生。涵盖的领域：这篇综述概述了各种支架材料，其机械性能以及在心脏贴片工程中使用的制造方法。总结了临床试验中的干细胞疗法和市售的心脏贴片材料，以期为心力衰竭的治疗提供最新的见解。到目前为止，示意性地图示了用于构造可行的厚心脏补丁的各种组织工程策略。专家意见：尽管已提出了许多用于制造各种心脏支架材料的策略，但疾病状况的阶段和严重性要求在合适的支架材料中加入其他提示。支架可以是纳米纤维贴剂，水凝胶或定制设计的膜。干细胞和生物分子提示与支架的整合可能为修复不健康的左心室组织并促进其再生提供正确的微环境。

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