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首页> 外文期刊>Geburtshilfe und Frauenheilkunde >Circulating Tumor Cells in Early-Stage Breast CancerKlinische Relevanz von zirkulierenden Tumorzellen beim Mammakarzinom
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Circulating Tumor Cells in Early-Stage Breast CancerKlinische Relevanz von zirkulierenden Tumorzellen beim Mammakarzinom

机译:早期乳腺癌中的循环肿瘤细胞乳腺癌中循环肿瘤细胞的临床相关性

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摘要

Disseminated tumor cells (DTC) are routinely detected in bone marrow (BM) in 30-40% of primary breast cancer patients. Positive BM status at the time of diagnosis as well as DTC persistence after therapy are strong independent prognostic factors. Since repeated BM aspirations are not well tolerated, detection of single tumor cells in peripheral blood (circulating tumor cells; CTC) have become of interest in recent years. CTC are found in 10-80% breast cancer patients. Variability can be explained by stage of the disease and detection method. Emerging data have shown CTC to be of prognostic relevance for both, patients with primary and metastatic disease. The assessment of CTC in blood may become an important biomarker for prognostication and therapy monitoring. Determination of their molecular characteristics will enable specific targeting of minimal residual as well as metastatic disease. This review summarizes recent research and future perspectives.
机译:通常在30-40%的原发性乳腺癌患者的骨髓(BM)中检测到已扩散的肿瘤细胞(DTC)。诊断时BM的阳性状态以及治疗后DTC的持久性是很强的独立预后因素。由于不能很好地耐受重复的BM抽吸,因此近年来对检测外周血中单个肿瘤细胞(循环肿瘤细胞; CTC)的兴趣已引起关注。在10-80%的乳腺癌患者中发现了四氯化碳。变异性可​​以通过疾病的阶段和检测方法来解释。新兴数据表明,对于原发性和转移性疾病患者,CTC与预后相关。血液中四氯化碳的评估可能成为预后和治疗监测的重要生物标志物。确定它们的分子特征将能够针对性地靶向最小的残留以及转移性疾病。这篇综述总结了最近的研究和未来的观点。

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