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Pedigree analysis for conservation of genetic diversity and purging

机译：保护遗传多样性和清除的家谱分析

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摘要

We present an approach to describe and evaluate changes in genetic diversity and to calculate bounds for improvement. This pedigree-based analysis was applied to the Kromfohrlander dog (FCI Gr9 Sec10). Pedigrees trace back to the foundation of the breed and were available for 5527 individuals. Based on this dataset the population structure and historical bottlenecks were Studied. Distributions of allele frequencies were estimated by Monte Carlo simulation. To monitor changes in mating systems throughout the breeding history, the homozygosity of alleles was compared with their expectations in Hardy-Weinberg equilibrium. Different breeding lines were identified by hierarchical cluster analysis and were characterized by ancestor contributions. Our calculations showed that the founder event in 1945 was followed by two bottlenecks. One Was caused by strong selection in a very small population, and the other was triggered by rigorous disease management. The necessary amount of purging that arised due to the bottlenecks was also discussed.
机译：我们提出一种方法来描述和评估遗传多样性的变化并计算改善的界限。基于谱系的分析应用于Kromfohrlander狗（FCI Gr9 Sec10）。家谱可追溯至该品种的基础，可供5527个人使用。基于此数据集，研究了人口结构和历史瓶颈。等位基因频率的分布通过蒙特卡洛模拟进行估计。为了监测整个育种历史中交配系统的变化，将等位基因的纯合性与其在Hardy-Weinberg平衡中的期望进行了比较。通过层次聚类分析确定不同的育种系，并以祖先的贡献为特征。我们的计算结果表明，1945年的创始事件之后有两个瓶颈。一种是由极少数人口中的强选择引起的，另一种是由严格的疾病管理触发的。还讨论了由于瓶颈而产生的必要清除量。

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