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首页> 外文期刊>Genes to cells : >Positional cloning of silkworm white egg 2 (w-2) locus shows functional conservation and diversification of ABC transporters for pigmentation in insects.
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Positional cloning of silkworm white egg 2 (w-2) locus shows functional conservation and diversification of ABC transporters for pigmentation in insects.

机译：蚕白卵2 （ w-2 ）基因座的位置克隆显示了昆虫色素沉着的ABC转运蛋白的功能保守和多样化。

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摘要

The white, scarlet and brown genes of Drosophila melanogaster encode three half-type ATP-binding cassette (ABC) transporters. In Drosophila, precursors of ommochromes and pteridines are transported by White/Scarlet and White/Brown heterodimers, respectively. The white egg 2 (w-2) mutant of the silkworm, Bombyx mori, has white eggs and eyes because of lack of ommochrome granules in the serosa and eyes. Here, we report that the silkworm w-2 locus encodes an ortholog of Drosophila scarlet. Our results indicate that Bombyx Scarlet forms a heterodimer with Bombyx White to transport ommochrome precursors, suggesting that formation of a White/Scarlet heterodimer and its involvement in the transport of ommochrome precursors are evolutionarily ancient and widely conserved traits in insects. Contrary to dipteran insects, white and scarlet were juxtaposed in a head-to-tail orientation in the silkworm genome, suggesting that the origin of white and scarlet was a tandem duplication of their ancestral transporter gene. In Bombyx, White is also essential for the transport of uric acid in larval epidermis. However, our results suggest that a Bombyx White/Scarlet heterodimer is not involved in this process. Our results emphasize the functional conservation and diversification of half-type ABC transporter families in insects, which may contribute to their extremely diverse color patterns.
机译：果蝇的白色，猩红和棕色基因编码三个半型ATP结合盒（ABC）运输者。在果蝇中，全色素和蝶啶的前体分别通过White / Scarlet和White / Brown异二聚体转运。家蚕的白卵2 （ w-2 ）突变体 Bombyx mori 具有白卵和眼睛，这是因为其体内缺乏全色素颗粒。浆膜和眼睛。在这里，我们报道了蚕 w-2 的基因座编码了果蝇猩红的直系同源物。我们的结果表明， Bombyx 猩红色与 Bombyx White形成异源二聚体，以转运ommochrome前体，这表明White / Scarlet异源二聚体的形成及其参与ommochrome前体的转运是在昆虫中具有进化的古老和广泛保存的性状。与二倍体昆虫相反， white 和 scarlet 在家蚕基因组中从头到尾并列排列，这表明 white 的起源和猩红是其祖传基因的串联复制。在 Bombyx 中，白色对于幼虫表皮中尿酸的运输也是必不可少的。但是，我们的结果表明， Bombyx White / Scarlet异二聚体不参与该过程。我们的研究结果强调了昆虫中半型ABC转运蛋白家族的功能保守和多样化，这可能有助于其极为多样的颜色模式。

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