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首页> 外文期刊>Genes to cells : >Cold exposure down-regulates zebrafish pigmentation
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Cold exposure down-regulates zebrafish pigmentation

机译：寒冷暴露下调了斑马鱼的色素沉着

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摘要

Vertebrates use adaptive mechanisms when exposed to physiologic stresses. However, the mechanisms of pigmentation regulation in response to physiologic stresses largely remain unclear. To address this issue, we developed a novel pigmentation model in adult zebrafish using coldwater exposure (cold zebrafish). When zebrafish were maintained at 17 degrees C, the pigmentation of their pigment stripes was reduced compared with zebrafish at 26.5 degrees C (normal zebrafish). In cold zebrafish, gene expression levels of tyrosinase and dopachrome tautomerase, which encode enzymes involved in melanogenesis, were down-regulated, suggesting that either down-regulation of melanin synthesis occurred or the number of melanophores decreased. Both regular and electron microscopic observation of zebrafish skin showed that the number of melanophores decreased, whereas aggregation of melanosomes was not changed in cold zebrafish compared with normal zebrafish. Taken together, we here show that cold exposure down-regulated adult zebrafish pigmentation through decreasing the number of melanophores and propose that the cold zebrafish model is a powerful tool for pigmentation research.
机译：脊椎动物在遭受生理压力时会使用适应性机制。然而，响应生理压力的色素沉着调节机制在很大程度上仍不清楚。为了解决这个问题，我们开发了一种使用冷水暴露（冷斑马鱼）的成年斑马鱼色素沉着模型。当斑马鱼保持在17摄氏度时，与26.5摄氏度的斑马鱼（正常斑马鱼）相比，它们的色素斑的色素沉着减少了。在冷斑马鱼中，编码涉及黑色素生成的酶的酪氨酸酶和多巴色素互变异构酶的基因表达水平被下调，表明发生黑色素合成的下调或黑素细胞的数量减少。斑马鱼皮肤的常规和电子显微镜观察均表明，与正常斑马鱼相比，冷斑马鱼中黑素体的数量减少了，而黑素体的聚集却没有改变。两者合计，我们在这里表明冷暴露通过减少黑素细胞的数目而下调了成年斑马鱼的色素沉着，并提出了冷斑马鱼模型是进行色素沉着研究的有力工具。

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