...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genes to cells : >Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance
【24h】

Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance

机译：火烈鸟，一种七遍跨膜钙粘着蛋白，与Netrin / Frazzled在果蝇中线指导中合作

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

During central nervous system development, several guidance cues and receptors, as well as cell adhesion molecules, are required for guiding axons across the midline and along the anterior-posterior axis. In Drosophila, commissural axons sense the midline attractants Netrin A and B (Net) through Frazzled (Fra) receptors. Despite their importance, lack of Net or fra affects only some commissures, suggesting that additional molecules can fulfill this function. Recently, planar cell polarity (PCP) proteins have been implicated in midline axon guidance in both vertebrate and invertebrate systems. Here, we report that the atypical cadherin and PCP molecule Flamingo/Starry night (Fmi/Stan) acts jointly with Net/Fra signaling during midline development. Additional removal of fmi strongly increases the guidance defects in Net/fra mutants. Rescue and domain deletion experiments suggest that Fmi signaling facilitates commissural pathfinding potentially by mediating axonal fasciculation in a partly homophilic manner. Altogether, our results indicate that contact-mediated cell adhesion via Fmi acts in addition to the Net/Fra guidance system during axon pathfinding across the midline, underlining the importance of PCP molecules during vertebrates and invertebrates midline development.
机译：在中枢神经系统发育期间，需要多个引导线索和受体以及细胞粘附分子来引导轴突穿过中线并沿着前后轴。在果蝇中，连合轴突通过Frazzled（Fra）受体感知中线引诱剂Netrin A和B（Net）。尽管它们很重要，但是缺少Net或fra只会影响某些连合，这表明其他分子可以实现此功能。最近，在脊椎动物和无脊椎动物系统中，平面细胞极性（PCP）蛋白已牵涉到中线轴突导向中。在这里，我们报告非典型钙粘蛋白和PCP分子火烈鸟/繁星之夜（Fmi / Stan）在中线发育过程中与Net / Fra信号传导共同起作用。额外去除fmi会大大增加Net / fra突变体中的指导缺陷。抢救和域删除实验表明，Fmi信号传导可能通过部分同源的方式介导轴突束疏松，从而促进连合寻路。总之，我们的结果表明，在整个中线的轴突寻路过程中，通过Fmi进行的接触介导的细胞粘附除了Net / Fra引导系统外，还发挥了脊椎动物和无脊椎动物中线发育过程中PCP分子的重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号