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首页> 外文期刊>Genes, brain, and behavior >Functional (GT)n polymorphisms in promoter region of N-methyl-d-aspartate receptor 2A subunit (GRIN2A) gene affect hippocampal and amygdala volumes.
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Functional (GT)n polymorphisms in promoter region of N-methyl-d-aspartate receptor 2A subunit (GRIN2A) gene affect hippocampal and amygdala volumes.

机译：N-甲基-d-天冬氨酸受体2A亚基（GRIN2A）基因的启动子区域中的功能（GT）n多态性影响海马和杏仁核的体积。

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摘要

The glutamate system including N-methyl-d-aspartate (NMDA) affects synaptic formation, plasticity and maintenance. Recent studies have shown a variable (GT)n polymorphism in the promoter region of the NMDA subunit gene (GRIN2A) and a length-dependent inhibition of transcriptional activity by the (GT)n repeat. In the present study, we examined whether the GRIN2A polymorphism is associated with regional brain volume especially in medial temporal lobe structures, in which the NMDA-dependent synaptic processes have been most extensively studied. Gray matter regions of interest (ROIs) for the bilateral amygdala and hippocampus were outlined manually on the magnetic resonance images of 144 healthy individuals. In addition, voxel-based morphometry (VBM) was conducted to explore the association of genotype with regional gray matter volume from everywhere in the brain in the same sample. The manually measured hippocampal and amygdala volumes were significantly larger in subjects with short allele carriers (n = 89) than in those with homozygous long alleles (n = 55) when individual differences in intracranial volume were accounted for. The VBM showed no significant association between the genotype and regional gray matter volume in any brain region. These findings suggest that the functional GRIN2A (GT)n polymorphism could weakly but significantly impact on human medial temporal lobe volume in a length-dependent manner, providing in vivo evidence of the role of the NMDA receptor in human brain development.
机译：包括N-甲基-d-天冬氨酸（NMDA）在内的谷氨酸系统影响突触的形成，可塑性和维持能力。最近的研究表明，NMDA亚基基因（GRIN2A）的启动子区域存在可变的（GT）n多态性，并且（GT）n重复序列对转录活性具有长度依赖性。在本研究中，我们检查了GRIN2A多态性是否与区域大脑体积有关，特别是在内侧颞叶结构中，其中对NMDA依赖性突触过程的研究最为广泛。在144位健康个体的磁共振图像上手动勾画了双侧杏仁核和海马体的感兴趣的灰质区域（ROIs）。此外，进行了基于体素的形态计量学（VBM），以探索同一样本中来自大脑各处的基因型与区域灰质体积的关联。当考虑到颅内体积的个体差异时，具有短等位基因携带者（n = 89）的受试者的手动测量的海马和杏仁核体积显着大于具有纯合长等位基因携带者（n = 55）的受试者。 VBM在任何大脑区域的基因型和区域灰质体积之间均无显着相关性。这些发现表明功能性GRIN2A（GT）n多态性可以以长度依赖的方式弱但显着地影响人类颞叶内侧体积，为NMDA受体在人类大脑发育中的作用提供了体内证据。

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