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首页> 外文期刊>Genes, brain, and behavior >Raphe serotonin neuron-specific oxytocin receptor knockout reduces aggression without affecting anxiety-like behavior in male mice only
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Raphe serotonin neuron-specific oxytocin receptor knockout reduces aggression without affecting anxiety-like behavior in male mice only

机译：缝制性5-羟色胺神经元特异性催产素受体基因敲除仅在雄性小鼠中降低侵略性而不影响焦虑样行为

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Serotonin and oxytocin influence aggressive and anxiety-like behaviors, though it is unclear how the two may interact. That the oxytocin receptor is expressed in the serotonergic raphe nuclei suggests a mechanism by which the two neurotransmitters may cooperatively influence behavior. We hypothesized that oxytocin acts on raphe neurons to influence serotonergically mediated anxiety-like, aggressive and parental care behaviors. We eliminated expression of the oxytocin receptor in raphe neurons by crossing mice expressing Cre recombinase under control of the serotonin transporter promoter (Slc6a4) with our conditional oxytocin receptor knockout line. The knockout mice generated by this cross are normal across a range of behavioral measures: there are no effects for either sex on locomotion in an open-field, olfactory habituation/dishabituation or, surprisingly, anxiety-like behaviors in the elevated O and plus mazes. There was a profound deficit in male aggression: only one of 11 raphe oxytocin receptor knockouts showed any aggressive behavior, compared to 8 of 11 wildtypes. In contrast, female knockouts displayed no deficits in maternal behavior or aggression. Our results show that oxytocin, via its effects on raphe neurons, is a key regulator of resident-intruder aggression in males but not maternal aggression. Furthermore, this reduction in male aggression is quite different from the effects reported previously after forebrain or total elimination of oxytocin receptors. Finally, we conclude that when constitutively eliminated, oxytocin receptors expressed by serotonin cells do not contribute to baseline anxiety-like behaviors or maternal care.
机译：5-羟色胺和催产素会影响侵略性和焦虑样行为，尽管目前尚不清楚两者之间如何相互作用。催产素受体在血清素能神经元核中表达，暗示了一种机制，通过这种机制，两种神经递质可以协同影响行为。我们假设催产素作用于沟纹神经元上，以影响血清素介导的焦虑样，积极和父母照顾行为。我们通过将表达Cre重组酶的小鼠在血清素转运蛋白启动子（Slc6a4）的控制下与我们的条件催产素受体敲除系杂交，从而消除了沟纹神经元中催产素受体的表达。通过这种杂交产生的基因敲除小鼠在一系列行为学测量中都是正常的：在旷野，嗅觉习惯/不适应中，性别对运动没有影响，而在升高的O和迷宫中，令人惊讶的是，类似焦虑的行为。男性的侵略性严重不足：11种拉菲催产素受体基因敲除中只有一种表现出攻击性行为，而11种野生型中有8种表现出侵略性。相反，女性基因敲除没有显示出孕产妇行为或攻击行为的缺陷。我们的研究结果表明，催产素通过其对沟纹神经元的作用，是雄性入侵者而非男性入侵者的关键调节因子。此外，这种男性侵略性的减少与先前报道的前脑或完全消除催产素受体后的效果完全不同。最后，我们得出结论，当组成型消除时，由血清素细胞表达的催产素受体不会促进基线焦虑样行为或孕产妇保健。

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