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首页> 外文期刊>Genes, brain, and behavior >Sensation-seeking genes and physical activity in youth.
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Sensation-seeking genes and physical activity in youth.

机译：青年寻求感觉的基因和体育锻炼。

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Many studies examining genetic influences on physical activity (PA) have evaluated the impact of single nucleotide polymorphisms (SNPs) related to the development of lifestyle-related chronic diseases, under the hypothesis that they would be associated with PA. However, PA is a multidetermined behavior and associated with a multitude of health consequences. Thus, examining a broader range of candidate genes associated with a broader range of PA correlates may provide new insights into the genetic underpinnings of PA. In this study, we focus on one such correlate - sensation-seeking behavior. Participants (N = 1130 Mexican origin youth) provided a saliva sample and data on PA and sensation-seeking tendencies in 2008-2009. Participants were genotyped for 630 functional and tagging variants in the dopamine, serotonin and cannabinoid pathways. Overall 30% of participants (males - 37.6% and females - 22.0%) reported ≥60 min of PA on 5 of 7 days. After adjusting for gender, age and population stratification, and applying the Bayesian False Discovery Probability approach for assessing noteworthiness, four gene variants were significantly associated with PA. In a multivariable model, being male, having higher sensation-seeking tendencies and at least one copy of the minor allele for SNPs in angiotensin I-converting enzyme gene [ACE; rs8066276 odds ratio (OR) = 1.44; P = 0.012] and tryptophan hydroxylase 2 gene (TPH2; rs11615016 OR = 1.73; P = 0.021) were associated with increased likelihood of meeting PA recommendations. Participants with at least one copy of the minor allele for SNPs in synaptosomal-associated protein 25 gene (SNAP25; rs363035 OR = 0.53; P = 0.005) and cannabinoid receptor 1 gene (CNR1; rs6454672 OR = 0.62; P = 0.022) have decreased likelihood of meeting PA recommendations. Our findings extend current knowledge of the complex relationship between PA and possible genetic underpinnings.
机译：许多研究检验了遗传因素对身体活动（PA）的影响，并在与单核苷酸多态性（PA）相关的假设下，评估了与生活方式相关的慢性疾病发展相关的单核苷酸多态性（SNP）的影响。但是，PA是一种多种行为，与多种健康后果有关。因此，研究与更广泛的PA相关性相关的更广泛的候选基因可能为PA的遗传基础提供新的见解。在这项研究中，我们专注于这样一种相关的感觉寻求行为。参与者（N = 1130来自墨西哥的青年）提供了唾液样本，以及有关2008-2009年PA和寻求感觉倾向的数据。对参与者的多巴胺，5-羟色胺和大麻素途径中的630个功能和标记变体进行了基因分型。总共30％的参与者（男性-37.6％和女性-22.0％）在7天中的5天中报告了≥60分钟的PA。在根据性别，年龄和人群分层进行调整后，并应用贝叶斯错误发现概率方法评估关注度，发现有四个基因变异与PA显着相关。在多变量模型中，是男性，具有更高的寻求知觉倾向，并且至少有一个拷贝的血管紧张素I转换酶基因[ACE; rs8066276优势比（OR）= 1.44; P = 0.012]和色氨酸羟化酶2基因（TPH2; rs11615016 OR = 1.73; P = 0.021）与满足PA建议的可能性增加相关。突触体相关蛋白25基因（SNAP25; rs363035 OR = 0.53; P = 0.005）和大麻素受体1基因（CNR1; rs6454672 OR = 0.62; P = 0.022）中具有至少一个SNPs小等位基因拷贝的参与者减少了达到PA建议的可能性。我们的发现扩展了对PA与可能的遗传基础之间复杂关系的当前知识。

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