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首页> 外文期刊>Genes to cells : >Targeting ID2 expression triggers a more differentiated phenotype and reduces aggressiveness in human salivary gland cancer cells
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Targeting ID2 expression triggers a more differentiated phenotype and reduces aggressiveness in human salivary gland cancer cells

机译：靶向ID2表达可触发更分化的表型并降低人类唾液腺癌细胞的侵袭性

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摘要

Inhibitors of DNA-binding (ID) proteins are negative regulators of basic helix-loop-helix transcription factors and generally stimulate cell proliferation and inhibit differentiation. We previously determined that ID1 was highly expressed in aggressive salivary gland cancer (SGC) cells in culture. Here, we show that ID2 is also expressed in aggressive SGC cells. ID2 knockdown triggers important changes in cell behavior, that is, it significantly reduces the expression of N-cadherin, vimentin and Snail, induces E-cadherin expression and leads to a more differentiated phenotype exemplified by changes in cell shape. Moreover, ID2 knockdown almost completely suppresses invasion and the expression of matrix metalloproteinase 9. In conclusion, ID2 expression maintains an aggressive phenotype in SGC cells, and ID2 repression triggers a reduction in cell aggressiveness. ID2 therefore represents a potential therapeutic target during SGC progression. ID proteins are negative regulators of basic helix-loop-helix transcription factors and generally stimulate cell proliferation and inhibit differentiation. ID2 knockdown triggers important changes in cell behavior, that is, it significantly reduces the expression of N-cadherin, vimentin and Snail, induces E-cadherin expression and leads to a more differentiated phenotype exemplified by changes in cell shape. ID2 therefore represents a potential therapeutic target during SGC progression.
机译：DNA结合（ID）蛋白的抑制剂是基本螺旋-环-螺旋转录因子的负调节剂，通常刺激细胞增殖并抑制分化。我们先前确定ID1在培养的侵袭性涎腺癌细胞（SGC）细胞中高表达。在这里，我们显示ID2在侵略性SGC细胞中也表达。 ID2敲低触发细胞行为的重要变化，即，它显着降低N-钙黏着蛋白，波形蛋白和Snail的表达，诱导E-钙黏着蛋白表达，并导致更分化的表型，例如细胞形状的变化。而且，ID2的敲低几乎完全抑制了侵袭和基质金属蛋白酶9的表达。总而言之，ID2的表达在SGC细胞中保持了侵袭性表型，而ID2的阻抑触发了细胞侵袭性的降低。因此，ID2代表SGC进展期间的潜在治疗靶标。 ID蛋白是基本螺旋-环-螺旋转录因子的负调节剂，通常刺激细胞增殖并抑制分化。 ID2敲低触发细胞行为的重要变化，即，其显着降低N-钙黏着蛋白，波形蛋白和Snail的表达，诱导E-钙黏着蛋白表达，并导致更分化的表型，例如细胞形状的变化。因此，ID2代表SGC进展期间的潜在治疗靶标。

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