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首页> 外文期刊>Genes, brain, and behavior >Dopaminergic and brain-derived neurotrophic factor signalling in inbred mice exposed to a restricted feeding schedule.
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Dopaminergic and brain-derived neurotrophic factor signalling in inbred mice exposed to a restricted feeding schedule.

机译：多巴胺能和脑源性神经营养因子信号转导的近交小鼠的喂养时间表受到限制。

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Increased physical activity and decreased motivation to eat are common features in anorexia nervosa. We investigated the development of these features and the potential implication of brain-derived neurotrophic factor (BDNF) and dopaminergic signalling in their development in C57BL/6J and A/J inbred mice, using the 'activity-based anorexia' model. In this model, mice on a restricted-feeding schedule are given unlimited access to running wheels. We measured dopamine receptor D2 and BDNF expression levels in the caudate putamen and the hippocampus, respectively, using in situ hybridization. We found that in response to scheduled feeding, C57BL/6J mice reduced their running wheel activity and displayed food anticipatory activity prior to food intake from day 2 of scheduled feeding as an indication of motivation to eat. In contrast, A/J mice increased running wheel activity during scheduled feeding and lacked food anticipatory activity. These were accompanied by increased dopamine receptor D2 expression in the caudate putamen and reduced BDNF expression in the hippocampus. Consistent with human linkage and association studies on BDNF and dopamine receptor D2 in anorexia nervosa, our study shows that dopaminergic and BDNF signalling are altered as a function of susceptibility to activity-based anorexia. Differences in gene expression and behaviour between A/J and C57BL/6J mice indicate that mouse genetic mapping populations based on these progenitor lines are valuable for identifying molecular determinants of anorexia-related traits.
机译：增加运动量和减少进食动机是神经性厌食症的常见特征。我们使用“基于活动的厌食症”模型研究了这些特征的发展以及脑源性神经营养因子（BDNF）和多巴胺能信号在C57BL / 6J和A / J近交小鼠的发育中的潜在意义。在这种模型中，限制喂食时间表的老鼠可以不受限制地使用跑步轮。我们使用原位杂交分别测量了尾状壳和海马中的多巴胺受体D2和BDNF表达水平。我们发现，对预定喂食有反应，C57BL / 6J小鼠在计划喂食的第2天开始进食之前，降低了其运转轮的活动并显示出预期的进食活性，以此作为进食动机的指标。相反，A / J小鼠在计划的进食期间增加了跑轮活动，并且缺乏预期的食物活动。这些伴随着尾状壳中多巴胺受体D2表达的增加和海马区BDNF表达的减少。与人类对神经性厌食症中BDNF和多巴胺受体D2的联系和关联研究相一致，我们的研究表明，多巴胺能和BDNF信号传导因活动性厌食症易感性而改变。 A / J和C57BL / 6J小鼠之间基因表达和行为的差异表明，基于这些祖细胞系的小鼠遗传作图群体对于鉴定厌食相关性状的分子决定因素非常有价值。

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