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首页> 外文期刊>Genes, Chromosomes and Cancer >Prostate cancer aggressiveness locus on chromosome segment 19q12-q13.1 identified by linkage and allelic imbalance studies.
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Prostate cancer aggressiveness locus on chromosome segment 19q12-q13.1 identified by linkage and allelic imbalance studies.

机译：通过连锁和等位基因失衡研究鉴定了染色体区段19q12-q13.1上的前列腺癌侵袭性位点。

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Whole-genome scan studies recently identified a locus on chromosome segments 19q12-q13.11 linked to prostate tumor aggressiveness by use of the Gleason score as a quantitative trait. We have now completed finer-scale linkage mapping across this region that confirmed and narrowed the candidate region to 2 cM, with a peak between markers D19S875 and D19S433. We also performed allelic imbalance (AI) studies across this region in primary prostate tumors from 52 patients unselected for family history or disease status. A high level of AI was observed, with the highest rates at markers D19S875 (56%) and D19S433 (60%). Furthermore, these two markers defined a smallest common region of AI of 0.8 Mb, with 15 (29%) prostate tumors displaying interstitial AI involving one or both markers. In addition, we noted a positive association between AI at marker D19S875 and extension of tumor beyond the margin (P = 0.02) as well as a higher Gleason score (P = 0.06). These data provide strong evidence that we have mapped aprostate tumor aggressiveness locus to chromosome segments 19q12-q13.11 that may play a role in both familial and non-familial forms of prostate cancer. Copyright 2003 Wiley-Liss, Inc.
机译：全基因组扫描研究最近通过使用格里森评分作为定量特征，鉴定了与前列腺癌侵袭性相关的染色体区段19q12-q13.11的基因座。现在，我们已经完成了跨越该区域的更精细的连锁作图，从而确认了候选区域并将其缩小到2 cM，并且在标记D19S875和D19S433之间出现了一个峰。我们还在未选择家族史或疾病状态的52位患者的原发性前列腺肿瘤中进行了该区域的等位基因失衡（AI）研究。观察到高水平的AI，标记物D19S875（56％）和D19S433（60％）的发生率最高。此外，这两种标记物定义了AI的最小共同区域为0.8 Mb，其中15个（29％）前列腺肿瘤表现出涉及一种或两种标记物的间质性AI。此外，我们注意到标记D19S875上的AI与肿瘤延伸超过边缘（P = 0.02）以及较高的Gleason评分（P = 0.06）之间呈正相关。这些数据提供了强有力的证据，表明我们已将前列腺癌的侵袭性基因座定位在染色体片段19q12-q13.11上，这些染色体片段可能在家族和非家族形式的前列腺癌中都起作用。版权所有2003 Wiley-Liss，Inc.

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