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首页> 外文期刊>European archives of oto-rhino-laryngology: Official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) >An exploratory study of the influence of clinico-demographic variables on swallowing and swallowing-related quality of life in a cohort of oral and oropharyngeal cancer patients treated with primary surgery.
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An exploratory study of the influence of clinico-demographic variables on swallowing and swallowing-related quality of life in a cohort of oral and oropharyngeal cancer patients treated with primary surgery.

机译：探索性临床人口统计学变量对吞咽和吞咽相关生活质量的影响的一组口腔癌和口咽癌患者接受了初次手术治疗。

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摘要

There are insufficient data on swallowing and the consequences of its dysfunction in patients with cancers of the oral cavity (OC) and oropharynx (OP) that are treated with primary surgery. The study attempts to explore the effect of important clinico-demographic variables on post-treatment swallowing and related quality of life (QOL) in post-surgical OC and OP cancer patients. Sixty-two consecutive OC and OP cancer patients completed the MD Anderson Dysphagia Inventory (MDADI) questionnaire. Mean scores were computed. Comparison of scores based on mean ranks were performed using Mann-Whitney U test or Kruskal-Wallis test. Level of significance was set at P ≤ 0.02. Adjustments were made for multiple comparisons. Significantly worse mean (SD) QOL scores were observed in late T-stage (T3/T4) versus early T-stage (T1/T2) patients for global domain, physical domain, functional domain and emotional domains [44.4 (21.9) vs. 78.7 (22.7) (P < 0.001); 50.0 (9.4) vs. 75.9 (16.3), (P < 0.0001); 57.8 (20.6) vs. 84.1 (16.7), (P < 0.001) and 55.2 (18.0) vs. 78.5 (16.3), (P < 0.001)], respectively. Patients undergoing reconstruction versus without reconstruction had worse QOL scores; 58.8 (26.9) versus 79.5 (22.8), (P < 0.01); 61.2 (15.1) versus 76.4 (17.5), (P = 0.002); 65.4 (20.5) versus 86.3 (15.9), (P < 0.0001) and 63.3 (18.8) versus 79.8 (16.3), (P < 0.01), respectively, for global, physical, functional and emotional domains. Advanced T-stage, reconstruction, younger age and base of tongue tumours have a negative impact on post-treatment swallow function and related QOL in these patients.
机译：对于接受初次手术治疗的口腔癌（OC）和口咽癌（OP）的患者，吞咽及其功能障碍的后果方面的数据不足。该研究试图探讨重要的临床人口统计学变量对手术后OC和OP癌症患者吞咽及相关生活质量（QOL）的影响。连续62位OC和OP癌症患者完成了MD安德森吞咽困难量表（MDADI）调查表。计算平均分数。使用Mann-Whitney U检验或Kruskal-Wallis检验对基于平均等级的得分进行比较。显着性水平设定为P≤0.02。进行了多次比较的调整。在T末期（T3 / T4）与T末期早期（T1 / T2）患者的整体域，身体域，功能域和情感域的平均（SD）QOL评分显着较差[44.4（21.9）vs. 78.7（22.7）（P <0.001）; 50.0（9.4）和75.9（16.3），（P <0.0001）; 57.8（20.6）与84.1（16.7），（P <0.001）和55.2（18.0）与78.5（16.3），（P <0.001）]。接受重建和未重建的患者的QOL评分较差; 58.8（26.9）对79.5（22.8），（P <0.01）; 61.2（15.1）对76.4（17.5），（P = 0.002）;对于全局，身体，功能和情感领域，分别为65.4（20.5）对86.3（15.9），（P <0.0001）和63.3（18.8）对79.8（16.3），（P <0.01）。晚期T期，重建，年龄较小和舌头肿瘤的根基对这些患者的吞咽功能和相关的生活质量有负面影响。

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