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首页> 外文期刊>European archives of oto-rhino-laryngology: Official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) >Complementary determination of Epstein-Barr virus DNA load and serum markers for nasopharyngeal carcinoma screening and early detection in individuals at risk in Tunisia
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Complementary determination of Epstein-Barr virus DNA load and serum markers for nasopharyngeal carcinoma screening and early detection in individuals at risk in Tunisia

机译：补充测定爱泼斯坦-巴尔病毒DNA量和血清标志物以筛查和早期发现突尼斯高危人群

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Because nasopharyngeal carcinoma (NPC) has a close association with Epstein-Barr virus (EBV), measuring serum EBV DNA and anti-EBV serum marker concentrations could be a feasible method for NPC diagnosis, monitoring and probably screening especially in a community at risk. The aim of this study was to determine the EBV pattern in sporadic NPC and in high risk NPC Tunisian families in order to evaluate their risk factors and help for NPC screening. The rates of anti-EBV antibodies and EBV DNA were determined in the serum of 47 healthy members randomly selected from 23 NPC multiplex families with two or more affected members, 93 healthy Tunisian community controls chosen with the same age, sex and geographic origin as unaffected individuals and 66 EBV positive sporadic NPC patients whose serum was available before and after treatment. Unexpectedly, significant lower concentrations of anti-EA (Early Antigen) IgG and anti-VCA (Viral Capsid Antigen) IgG were found in unaffected members from NPC families than in healthy controls while viral loads were negative in all the tested sera. For sporadic NPC patients, anti-EA IgG and anti-VCA IgA concentrations were significantly higher than in healthy controls and these rates decreased after treatment. The level of EBV DNA load varied according to the condition of the tumour. This study suggests that in the Tunisian NPC families, screening for malignancy is based on serum concentrations but not on EBV DNA load while in the sporadic NPC group, serologic markers and EBV DNA load are complementary for diagnosis and follow-up.
机译：由于鼻咽癌（NPC）与爱泼斯坦-巴尔病毒（EBV）密切相关，因此测量血清EBV DNA和抗EBV血清标志物浓度可能是诊断，监测和筛查NPC的可行方法，尤其是在有危险的社区中。这项研究的目的是确定散发性鼻咽癌和高危鼻咽癌突尼斯家庭的EBV模式，以评估其危险因素并帮助进行鼻咽癌筛查。在从23个NPC多重家庭中随机选择的47个健康成员的血清中确定了抗EBV抗体和EBV DNA的比率，这些家庭有两个或多个受影响的成员，选择了93个健康的突尼斯社区对照，其年龄，性别和地理来源均未受影响个体和66例EBV阳性散发性NPC患者，其治疗前后均可获得血清。出乎意料的是，在未患病的NPC家庭成员中，抗EA（早期抗原）IgG和抗VCA（病毒衣壳抗原）IgG的浓度明显低于健康对照，而在所有测试血清中病毒载量均为阴性。对于散发的NPC患者，抗EA IgG和抗VCA IgA的浓度显着高于健康对照组，并且这些比率在治疗后降低。 EBV DNA负荷水平随肿瘤状况而变化。这项研究表明，在突尼斯NPC家族中，对恶性肿瘤的筛查是基于血清浓度而不是基于EBV DNA负荷，而在散发性NPC组中，血清学标志物和EBV DNA负荷是诊断和随访的补充。

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