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Molecular biology of gibberellins signaling in higher plants.

机译:赤霉素信号传导在高等植物中的分子生物学。

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Gibberellins (GAs), a large family of tetracyclic, diterpenoid plant hormones, play an important role in regulating diverse processes throughout plant development. In recent years, significant advances have been made in the isolation of GA signaling components and GA-responsive genes. All available data have indicated that DELLA proteins are an essential negative regulator in the GA signaling pathway and GA derepresses DELLA-mediated growth suppression by inducing degradation of DELLA proteins through the ubiquitin-26S proteasome proteolytic pathway. Identification of GID1, a gene encoding an unknown protein with similarity to hormone-sensitive lipases, has revealed that GID1 acts as a functional GA receptor with a reasonable binding affinity to biologically active GAs. Furthermore, the GID1 receptor interacts with DELLA proteins in a GA-dependent manner. These results suggest that formation of a GID1-GA-DELLA protein complex targets DELLA protein into the ubiquitin-26S proteasome pathway for degradation.
机译:赤霉素(GAs)是四环,二萜类植物激素的大家族,在调节整个植物发育的各种过程中起着重要作用。近年来,在GA信号转导成分和GA响应基因的分离方面取得了重大进展。所有可用数据均表明,DELLA蛋白是GA信号通路中必不可少的负调节剂,并且GA通过泛素26S蛋白酶体蛋白水解途径诱导DELLA蛋白降解,从而抑制DELLA介导的生长抑制。 GID1(一种编码与激素敏感脂肪酶相似的未知蛋白质的基因)的鉴定表明,GID1充当功能性GA受体,对生物活性GA具有合理的结合亲和力。此外,GID1受体以GA依赖性方式与DELLA蛋白相互作用。这些结果表明,GID1-GA-DELLA蛋白复合物的形成将DELLA蛋白靶向到遍在蛋白26S蛋白酶体途径中进行降解。

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