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首页> 外文期刊>Genesis: the journal of genetics and development >Sox10-iCreERT2: A mouse line to inducibly trace the neural crest and oligodendrocyte lineage
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Sox10-iCreERT2: A mouse line to inducibly trace the neural crest and oligodendrocyte lineage

机译：Sox10-iCreERT2：小鼠线，可诱导性地追踪神经c和少突胶质细胞谱系

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摘要

SOX10 is a well-conserved and widely expressed transcription factor involved in the regulation of embryonic development and in the determination of cell fate. As it is expressed in neural crest cells, their derivatives and the oligodendrocyte lineage, mutations of the protein contribute to a variety of diseases like neurocristopathies, peripheral demyelinating neuropathies, and melanoma. Here, we report the generation of an inducible Sox10-iCreERT2 BAC transgenic mouse line that labels, depending on the timepoint of induction, distinct derivatives of the otic placode and the neural crest as well as cells of the oligodendrocyte lineage. Surprisingly, we could show a neural crest origin of pericytes in the brain. Besides its use for fate-mapping, the Sox10-iCreERT2 mouse line is a powerful tool to conditionally inactivate genes in the neural crest cells, their progeny and/or the oligodendrocyte lineage in a time-dependent fashion to gain further insights into their function and contribution to diseases. genesis 50:506515, 2012. (C) 2011 Wiley Periodicals, Inc.RI Lickert, Heiko/K-9045-2013
机译：SOX10是一种保守且广泛表达的转录因子，参与胚胎发育的调控和细胞命运的确定。由于它在神经cells细胞，其衍生物和少突胶质细胞谱系中表达，因此该蛋白的突变会导致多种疾病，例如神经risto病，周围性脱髓鞘性神经病和黑色素瘤。在这里，我们报道了诱导型Sox10-iCreERT2 BAC转基因小鼠品系的生成，该品系根据诱导的时间点，耳廓和神经c以及少突胶质细胞谱系的不同细胞进行标记。令人惊讶的是，我们可以显示出大脑周细胞的神经c起源。除了用于命运映射，Sox10-iCreERT2小鼠系还是功能强大的工具，可以以时间依赖的方式有条件地灭活神经c细胞，其子代和/或少突胶质细胞系中的基因，以进一步了解其功能和功能。对疾病的贡献。创世纪50：506515，2012.（C）2011 Wiley Periodicals，Inc.RI Lickert，Heiko / K-9045-2013

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