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首页> 外文期刊>European Journal of Lipid Science and Technology >Antimicrobial properties of 1-monoacylglycerols prepared from undecanoic (C11:0) and undecenoic (C11:1) acid
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Antimicrobial properties of 1-monoacylglycerols prepared from undecanoic (C11:0) and undecenoic (C11:1) acid

机译：由十一酸（C11：0）和十一碳（C11：1）酸制备的1-单酰基甘油的抗菌性能

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摘要

Antimicrobial activity of monoacylglycerols (MAG) with odd number of carbons prepared from undecanoic (MAG C11:0) and undecenoic (MAG C11:1) was investigated. Data showed that both studied substances successfully inhibited Gram-positive cocci (Staphylococcus aureus) and spore-forming rods (Bacillus cereus). Gram-negative bacteria were highly resistant against MAG CI 1:0 and showed considerable tolerance against MAG C11:1. Minimum inhibitory concentration (MIC) of MAG C11:1 was possible to determine for Escherichia colt only. Complete inhibition of three fungi genera (Altemaria, Cladosporium, Trichothecium) was achieved using MAG CI 1:1 with a concentration higher than 750 μg/ mL. The growth of Aspergillus niger, Mucor racemosus, Phoma, Scopulariopsis, Trichoderma was significantly reduced. Generally, MAG C11:1 was more efficient than MAG C11:0 against all tested microorganisms. Due to a rich production of degradation enzymes, some fungi species surprisingly adapted their metabolism during growth and were even able to utilise tested MAG as a source of carbon.Practical applications: MAG composed of fatty acids witii odd number of carbons in molecule are a promising group of substances applicable in food industry and cosmetics. They represent materials with broad spectrum of antimicrobial activity, especially against Gram-positive bacteria. More efficient MAG C11:1 with a double bond in molecule can be recommended for reduction of S. aureus that cause food enterotoxicosis.
机译：研究了由十一碳酸（MAG C11：0）和十一碳酸（MAG C11：1）制备的具有奇数碳原子的单酰基甘油（MAG）的抗菌活性。数据显示，两种研究物质均能成功抑制革兰氏阳性球菌（金黄色葡萄球菌）和芽孢棒（蜡状芽孢杆菌）。革兰氏阴性细菌对MAG CI 1：0高度耐药，对MAG C11：1表现出相当大的耐受性。 MAG C11：1的最小抑菌浓度（MIC）可能仅针对大肠埃希氏菌即可确定。使用浓度高于750μg/ mL的MAG CI 1：1，可以完全抑制三种真菌属（Altemaria，Cladosporium，Trichothecium）。黑曲霉，Mucor racemosus，Phoma，Scopulariopsis，木霉的生长显着降低。通常，对于所有测试的微生物，MAG C11：1比MAG C11：0更有效。由于降解酶的大量产生，一些真菌种类出人意料地在生长过程中适应了它们的代谢，甚至能够利用经过测试的MAG作为碳源。实际应用：由脂肪酸和分子中奇数碳组成的MAG是很有前途的适用于食品工业和化妆品的一组物质。它们代表具有广谱抗菌活性的材料，尤其是针对革兰氏阳性细菌的材料。可以建议使用分子中具有双键的更有效的MAG C11：1来减少引起食物肠中毒的金黄色葡萄球菌。

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