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首页> 外文期刊>Genomics >Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci.
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Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci.

机译：盐诱导的高血压鼠定量特征基因座与大鼠和人类基因座的一致性。

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To investigate the genetic control of salt-induced hypertension, we performed a quantitative trait locus analysis on male mice from a reciprocal backcross between the salt-sensitive C57BL/6J and the normotensive A/J inbred mouse strains after they were provided with water containing 1% salt for 2 weeks. Genome-wide scans performed on these mice and analyzed with a combination of conventional marker-based regressions and a novel simultaneous search for pairs revealed six significant quantitative trait loci associated with salt-induced blood pressure, two of which were interacting loci. These six loci, named Bpq1-6 for blood pressure quantitative trait loci, mapped to D1Mit334, D1Mit14, D4Mit164, D5Mit31, D6Mit15, and D15Mit13. Furthermore, five of these six loci were concordant with hypertension loci in rats, and four were concordant with hypertension loci in humans, suggesting that quantitative trait loci mapping in model organisms can be used to guide the search for human blood pressure genes. Copyright 2001 Academic Press.
机译：为了研究盐诱导的高血压的遗传控制，我们对雄性小鼠进行了定量性状基因座分析，该雄性小鼠从对盐敏感的C57BL / 6J和血压正常的A / J自交系小鼠品系中分别添加了1 ％盐2周。对这些小鼠进行了全基因组扫描，并结合了常规基于标记的回归分析和新颖的配对搜索进行了分析，结果发现与盐诱导的血压相关的六个重要的定量性状基因座，其中两个是相互作用的基因座。这六个基因座，被称为血压定量性状基因座的Bpq1-6，映射到D1Mit334，D1Mit14，D4Mit164，D5Mit31，D6Mit15和D15Mit13。此外，这六个基因座中的五个与大鼠中的高血压基因座一致，而在人类中的四个中与高血压基因座一致，这表明模型生物中的定量性状基因座作图可用于指导人类血压基因的搜索。版权所有2001，学术出版社。

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