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首页> 外文期刊>Genomics >Transcript map of the 8p23 putative tumor suppressor region.
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Transcript map of the 8p23 putative tumor suppressor region.

机译：8p23推定的肿瘤抑制区域的转录本图谱。

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摘要

Cancers of the head and neck, prostate, liver, and bladder exhibit minimal regions of deletion within chromosomal band 8p23 that either overlap or map very close to one another. We previously refined a minimal region of deletion in squamous cell carcinomas to a 112-kb interval within 8p23. There seems to be only a single gene within this region that is expressed in normal upper aerodigestive tract epithelium. This candidate for the squamous cancer suppressor, CUB and sushi multiple domains-1 (CSMD1), extends into the minimal regions of deletions defined for the other types of cancer with 8p23 deletions. RT-PCR and EST data indicate that CSMD1 is also expressed in those organs,making this gene a candidate for a suppressor of multiple types of cancer. Both the sequence of the gene and the organization of the protein are highly conserved in the mouse.
机译：头颈癌，前列腺癌，肝癌和膀胱癌在染色体带8p23内表现出极少的缺失区域，这些区域要么重叠要么彼此非常接近。我们以前在8p23内将鳞状细胞癌的最小缺失区域精确到112-kb。在该区域内似乎只有一个基因在正常的上消化道上皮中表达。鳞状癌抑制物，CUB和sushi多结构域-1（CSMD1）的候选基因延伸到为其他类型的具有8p23缺失的癌症定义的最小缺失区域。 RT-PCR和EST数据表明CSMD1也在那些器官中表达，使该基因成为抑制多种类型癌症的候选基因。基因的序列和蛋白质的组织在小鼠中都是高度保守的。

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