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首页> 外文期刊>Genomics >Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior.
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Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior.

机译：PEG3的印迹，PEG3是参与培养行为的小鼠基因的人类同源物。

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The paternally expressed Peg3 gene in mice encodes an unusual Kruppel-type zinc finger protein implicated in critical cellular and behavioral functions including growth, apoptosis, and maternal nurturing behavior. Methylation and expression analyses were used to determine whether PEG3 on chromosome 19q13.4 is imprinted in humans. The PEG3 promoter is encompassed within a large CpG-rich region that is differentially methylated in fetal tissues. Furthermore, expression studies demonstrate that PEG3 is ubiquitously imprinted throughout development and postnatally. Multiple isoforms of the PEG3 gene, including a novel transcript, are paternally expressed. These results are the first to show that human chromosome 19q13.4 contains an imprinted region. The imprinted status of PEG3 throughout life coupled with its neural expression and putative roles in regulating cell growth suggests that PEG3 may be a susceptibility locus for cancer as well as neurobehavioral deficits. Copyright 2001 Academic Press.
机译：小鼠中父本表达的Peg3基因编码一种异常的Kruppel型锌指蛋白，涉及关键的细胞和行为功能，包括生长，凋亡和母体养育行为。甲基化和表达分析用于确定19q13.4染色体上的PEG3是否在人类中被印记。 PEG3启动子包含在一个大的富含CpG的区域内，该区域在胎儿组织中被甲基化。此外，表达研究表明，PEG3在整个发育过程中和出生后无处不在。父本表达了PEG3基因的多种同工型，包括一个新的转录本。这些结果首次表明人染色体19q13.4包含一个印迹区域。整个生命中PEG3的印迹状态及其在调节细胞生长中的神经表达和假定作用表明PEG3可能是癌症以及神经行为缺陷的易感位点。版权所有2001，学术出版社。

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