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首页> 外文期刊>European journal of mass spectrometry >Fingerprinting of 3, 4-methylenedioxy-methamphetamine markers by desorption/ionization on porous silicon
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Fingerprinting of 3, 4-methylenedioxy-methamphetamine markers by desorption/ionization on porous silicon

机译：通过在多孔硅上解吸/电离对3，4-亚甲二氧基-甲基苯丙胺标记物的指纹图谱

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摘要

Desorption/ionization on porous silicon (DIOS) is a method which extends the application range of matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. This technique eliminates matrix background in the low mass range; DIOS is especially advantageous in research on small organic molecules and their metabolites in biological samples. DIOS mass spectrometry was applied for 3, 4-methylenedioxymethamphetamine, (MDMA, Ecstasy) impurities identification. Trace component profiling enables the identification of by-product characteristics for the synthesis route of MDMA. Ecstasy, a synthetic psychoactive drug, is highly popular among young people, and often used as a recreational drug, most commonly during disco parties. MDMA enhances feeling of euphoria by increasing the level of neurotransmitters such as serotonin, dopamine and norepinephrine and causes acute behavioral and psychological effects. MDMA is almost exclusively produced illegally, primarily in Western Europe. The new method for MDMA impurities profiling has been developed to trace the origin of MDMA pills. For comparison and classification of the impurity profiles, principal components analysis was used.
机译：多孔硅解吸/电离（DIOS）是一种扩展基质辅助激光解吸/电离飞行时间质谱仪的应用范围的方法。此技术消除了低质量范围内的基质背景; DIOS在研究有机样品中的有机小分子及其代谢产物方面特别有利。 DIOS质谱用于3，4-亚甲二氧基甲基苯丙胺（MDMA，摇头丸）杂质的鉴定。痕量成分分析可以识别MDMA合成路线的副产物特征。摇头丸是一种合成的精神活性药物，在年轻人中非常受欢迎，并且经常用作娱乐性药物，在迪斯科舞会期间最为常见。 MDMA通过增加神经递质（例如5-羟色胺，多巴胺和去甲肾上腺素）的水平来增强欣快感，并引起急性的行为和心理影响。 MDMA几乎完全是非法生产的，主要在西欧。已开发出用于MDMA杂质分析的新方法，以追踪MDMA药丸的起源。为了对杂质分布进行比较和分类，使用了主成分分析。

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