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首页> 外文期刊>Genomics >A sequence-based map of the nine genes of the human interleukin-1 cluster.
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A sequence-based map of the nine genes of the human interleukin-1 cluster.

机译：人白介素-1簇的九个基因的基于序列的图。

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Six novel genes encoding proteins with the interleukin (IL)-1 fold have been identified recently. The classical family members are involved in inflammatory signaling. Previous work has placed the novel genes close to or within the same cluster as IL1A, IL1B, and IL1RN, which occupy an approximately 400-kb interval on chromosome 2. We have combined the incomplete public database sequence with our own sequence to generate a reference sequence and map that encompass all of the novel genes, allowing determination of the gene structures, precise localization of exons, and determination of distances between conventional SNP and microsatellite markers. Gene order from centromere to telomere is IL1A-IL1B-IL1F7-IL1F9-IL1F6-IL1F8-IL1F5-IL1F10-IL1RN, of which only IL1A, IL1B, and IL1F8 are transcribed towards the centromere. The gene order relates to the volutionary relationship between the genes. Key features of exon boundaries are conserved. There is no evidence for other IL-1 family members within the cluster. (c)2002 Elsevier Science (USA).
机译：最近已鉴定出六个编码具有白介素（IL）-1折叠蛋白的新基因。经典家族成员参与炎症信号传导。先前的工作已将新基因置于与IL1A，IL1B和IL1RN相同或相似的簇中，它​​们在第2号染色体上占据了大约400 kb的间隔。我们将不完整的公共数据库序列与我们自己的序列结合起来以产生参考包含所有新基因的序列和图谱，从而可以确定基因结构，精确定位外显子以及确定常规SNP与微卫星标记之间的距离。从着丝粒到端粒的基因顺序是IL1A-IL1B-IL1F7-IL1F9-IL1F6-IL1F8-IL1F5-IL1F10-IL1RN，其中只有IL1A，IL1B和IL1F8被转录为着丝粒。基因顺序与基因之间的进化关系有关。外显子边界的关键特征得以保留。没有证据表明该群内还有其他IL-1家族成员。 （c）2002 Elsevier Science（美国）。

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