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首页> 外文期刊>European journal of mass spectrometry >A new electrostatic transfer line for improved transmission in Fourier transform laser microprobe mass spectrometry with external ion source
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A new electrostatic transfer line for improved transmission in Fourier transform laser microprobe mass spectrometry with external ion source

机译：一种新型静电传输线，可改善带有外部离子源的傅立叶变换激光微探针质谱中的传输

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The efficient extraction and transfer of ions from an external ion source outside the magnet and their injection through the inhomogeneous fringing field becomes a key factor in the micro-analytical application of Fourier transform mass spectrometry (FTMS) instruments with an external ion source. This paper reports on a new ion transfer line with static electrical fields for a source at a distance of 131 cm from the cylindrical ion cyclotron resonance (ICR) "Infinity" cell in an unshielded 4.7 Tesla superconducting magnet. Basically, ions are accelerated to 2-3 kV, transported through a time-of-flight (TOF) system and decelerated at the entrance of the magnet. The size of the system, the magnetic stray field and the significant electrical field gradients require careful optimisation of the simulations with the SIMION software. According to our calculations, the new ion transfer line should allow transport and trapping of ions initially emitted with an angle of up to 35° with the normal, as opposed to 5° with the former commercial transfer line with improved cylindrical front optics. The design has been experimentally verified using focused laser desorption/ionisation of solids. The data on reference compounds have demonstrated that the sensitivity with the new transfer line increases by a factor of 10. A substantial gain of sensitivity is also expected for other ionisation methods producing ions with a more isotropic angular emission than focused laser irradiation. The new ion optics are fully compatible with the existing hardware so that conversion becomes a minor operation.
机译：从磁体外部的外部离子源中有效地提取和转移离子，以及通过不均匀的边缘场进行注入，已成为具有外部离子源的傅里叶变换质谱（FTMS）仪器进行微分析应用的关键因素。本文报道了一条新的带有静电电场的离子传输线，该离子传输线用于未屏蔽的4.7 Tesla超导磁体中与圆柱离子回旋共振（ICR）“无限”单元相距131 cm的源。基本上，离子会加速到2-3 kV，通过飞行时间（TOF）系统传输，并在磁体入口处减速。系统大小，杂散磁场和明显的电场梯度需要使用SIMION软件仔细优化仿真。根据我们的计算，新的离子传输线应允许以最初与法线成最大35°的角度传输和捕获最初发射的离子，而以前的商用传输线具有改进的圆柱形前光学元件则为5°。该设计已通过使用聚焦激光解吸/电离固体进行了实验验证。有关参考化合物的数据表明，新传输线的灵敏度提高了10倍。对于其他产生离子性比聚焦激光辐照角度更大的离子的电离方法，也有望获得显着的灵敏度提高。新的离子光学器件与现有硬件完全兼容，因此转换成为次要操作。

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