Disruption of Apc10/Doc1 in three alleles of oligosyndactylism.

Pravtcheva DD; Wise TL

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Disruption of Apc10/Doc1 in three alleles of oligosyndactylism.

机译：Apc10 / Doc1在寡聚寡核苷酸的三个等位基因中的破坏。

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Oligosyndactylism (Os) is a radiation-induced mouse mutation associated with recessive lethality and a dominant effect on limb and kidney development. The lethal effect of the mutation is due to a cell-autonomous block in the transition from metaphase to anaphase. We have previously characterized two transgene-induced mutations, 94-A and 94-K, which are allelic with Os. These mutations facilitated the identification of genomic segments and transcribed sequences in the affected region. One of the transcripts in this region corresponds to the mouse homolog of the anaphase-promoting complex component APC10/DOC1. The disruption of this gene can explain the mitotic arrest phenotype of all three alleles of Os. Copyright 2001 Academic Press.

机译：少突触症（Os）是一种辐射诱发的小鼠突变，与隐性致死率相关，对肢体和肾脏发育起主要作用。突变的致死作用是由于从中期到后期的过渡过程中的细胞自主阻滞。我们以前已经表征了两个转基因诱导的突变，即94-A和94-K，它们与Os等位基因相同。这些突变有助于在受影响区域中鉴定基因组片段和转录序列。该区域中的转录物之一对应于后期促进复杂成分APC10 / DOC1的小鼠同源物。该基因的破坏可以解释Os所有三个等位基因的有丝分裂停滞表型。版权所有2001学术出版社。

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《Genomics》 |2001年第1期|共10页
作者
Pravtcheva DD; Wise TL;
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正文语种 eng
中图分类遗传学;
关键词
Abnormalities; Radiation-Induced; Alleles; Cell Cycle Proteins; Mutation; 畸形; 辐射性; 等位基因; 细胞周期蛋白质类; 突变;

机译：Abnormalities;Radiation-Induced;Alleles;Cell Cycle Proteins;Mutation;畸形;辐射性;等位基因;细胞周期蛋白质类;突变;

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1. Disruption of Apc10/Doc1 in three alleles of oligosyndactylism. [J] . Pravtcheva DD, Wise TL Genomics . 2001,第1期

机译：Apc10 / Doc1在寡聚寡核苷酸的三个等位基因中的破坏。
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机译：从表型到蛋白质折叠：伴侣蛋白和伴侣蛋白等位基因之间等位基因依赖性遗传相互作用的表征。
6. The pseudosubstrate inhibitor Acm1 inhibits the anaphase-promoting complex/cyclosome by combining high-affinity activator binding with disruption of Doc1/Apc10 function [O] . Liang Qin, Arda Mizrak, Dimitrius Santiago P. S. F. Guimarães, 2019

机译：通过将高亲和力激活因子结合与DOC1 / APC10功能的破坏组合伪升抑制剂ACM1抑制了促进的促进复合物/环体
7. Gene Editing–Mediated Disruption of Epidermolytic Ichthyosis–Associated KRT10 Alleles Restores Filament Stability in Keratinocytes [O] . Oliver P. March, Thomas Lettner, Alfred Klausegger, 2019

机译：基因编辑介导的表皮水解性ICHThyosis相关的KRT10等位基因恢复角质形成细胞的灯丝稳定性

Disruption of Apc10/Doc1 in three alleles of oligosyndactylism.

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