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首页> 外文期刊>Genomics >GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13.
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GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13.

机译：GPC6是Glypican基因家族的新成员，它编码与GPC4结构相关的产物，并与GPC5在人类13号染色体上共定位。

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摘要

Glypicans are a family of cell surface heparan sulfate proteoglycans that appear to play an important role in cellular growth control and differentiation, as is supported by the observation that mutations in GPC3 are responsible for Simpson-Golabi-Behmel syndrome (SGBS) in humans. Recently it has been shown that the GPC4 gene is tightly clustered with GPC3 on the X chromosome and that some patients with SGBS apparently have deletions affecting both genes. We report here the identification of a human cDNA encoding a novel glypican family member, glypican-6. This cDNA encodes a predicted protein of 554 amino acids and is structurally analogous to other members of the glypican gene family, but most highly related to glypican-4. A single GPC6 mRNA of 6.2 kb is detected most abundantly in the ovary, liver, and kidney, with lower levels of mRNA expression also detected in a wide range of other adult tissues. Radiation hybrid analysis mapped the GPC6 gene to human chromosome 13 very near the GPC5 gene, a member of the glypican family bearing strong similarity to GPC3. Copyright 1999 Academic Press.
机译：Glypicans是一类细胞表面硫酸乙酰肝素蛋白聚糖家族，在细胞生长控制和分化中似乎起着重要作用，这一点得到以下观察结果的支持：GPC3中的突变与人类的Simpson-Golabi-Behmel综合征（SGBS）有关。最近已经显示，GPC4基因在X染色体上与GPC3紧密结合，并且一些SGBS患者显然具有影响这两个基因的缺失。我们在这里报告编码新型glypican家族成员glypican-6的人类cDNA的鉴定。该cDNA编码一个预测的554个氨基酸的蛋白，在结构上与glypican基因家族的其他成员相似，但与glypican-4高度相关。在卵巢，肝和肾中最丰富地检测到6.2 kb的单个GPC6 mRNA，在其他成年组织中也检测到了较低水平的mRNA表达。辐射杂交分析将GPC6基因定位在非常靠近GPC5基因的人13号染色体上，该基因是Glypican家族的成员，与GPC3有很强的相似性。版权所有1999 Academic Press。

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