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首页> 外文期刊>Genomics >High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains.
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High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains.

机译：使用达尔大鼠同系菌株对7号染色体上的血压QTL进行高分辨率定位。

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It was previously shown using Dahl salt-sensitive (S) and salt-resistant (R) rats that a blood pressure quantitative trait locus (QTL) was present on rat chromosome 7. In the present work, this QTL was localized to a region less than 0.54 cM in size on the linkage map using a series of congenic strains. This region was contained in a single yeast artificial chromosome that was 220 kb long. This small segment still contained the primary candidate locus Cyp11b1 (11beta-hydroxylase), but the adjacent candidate genes Cyp11b2 (aldosterone synthase) and Cyp11b3 were ruled out. It is concluded that 11beta-hydroxylase, through its known genetic variants altering the production of 18-hydroxy-11-deoxy corticosterone, is very likely to account for the blood pressure QTL on chromosome 7 in the Dahl rat model of hypertension. This QTL accounts for about 23 mm Hg under the condition of 2% NaCl diet for 24 days. Copyright 2001 Academic Press.
机译：先前已证明，使用Dahl盐敏感（S）和抗盐（R）的大鼠在大鼠7号染色体上存在血压定量性状基因座（QTL）。使用一系列同基因菌株，在连锁图上的大小为0.54 cM。该区域包含在一条220 kb长的酵母人工染色体中。这个小片段仍然包含主要候选基因Cyp11b1（11β-羟化酶），但排除了邻近的候选基因Cyp11b2（醛固酮合酶）和Cyp11b3。结论是11β-羟化酶通过其已知的遗传变异改变了18-羟基-11-脱氧皮质酮的产生，很可能解释了Dahl大鼠高血压模型中7号染色体上的血压QTL。在2％NaCl饮食条件下持续24天，此QTL约占23 mm Hg。版权所有2001学术出版社。

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