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首页> 外文期刊>Genomics >Characterize the relationship between essential and TATA-containing genes for S. cerevisiae by network topologies in the perturbation sensitivity network
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Characterize the relationship between essential and TATA-containing genes for S. cerevisiae by network topologies in the perturbation sensitivity network

机译：通过摄动敏感性网络中的网络拓扑表征酿酒酵母的必需基因和含TATA的基因之间的关系

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Essential genes are those that are indispensable for the survival and propagation of an organism. TATA-containing genes are associated with responses to various stresses and are highly regulated. Although both essential genes and TATA genes are very important in the function of biological systems, their relationship remains unclear because they have typically been researched independently. In this study, to investigate the relationship between essential genes and TATA genes, S. cerevisiae genes were classified as: essential TATA-containing, nonessential TATA-containing, essential non-TATA, and non-essential non-TATA genes. Network-based methods were applied to analyze these four gene categories in the S. cerevisiae perturbation sensitivity (PS) network, which was created from the transcriptional profiling of hundreds of different gene disruptions. All of the topological properties were found to be statistically discriminative among the four gene categories, and the non-essential TATA-containing genes had the most important roles in the yeast PS network. (C) 2016 Elsevier Inc. All rights reserved.
机译：必需基因是生物体生存和繁殖必不可少的基因。含有TATA的基因与对各种压力的反应相关，并且受到高度调控。尽管必需基因和TATA基因在生物系统的功能中都非常重要，但是它们之间的关系仍然不清楚，因为它们通常是独立研究的。在这项研究中，为了研究必需基因与TATA基因之间的关系，将酿酒酵母基因分类为：含必需TATA，含非必需TATA，必需非TATA和非必需非TATA基因。应用基于网络的方法来分析啤酒酵母微扰敏感性（PS）网络中的这四个基因类别，该网络是由数百种不同基因破坏的转录谱创建的。发现这四个基因类别之间的所有拓扑特性在统计学上都是可区分的，并且含有非必要TATA的基因在酵母PS网络中具有最重要的作用。 （C）2016 Elsevier Inc.保留所有权利。

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