Diet-induced weight loss leads to a switch in gene regulatory network control in the rectal mucosa

Vargas Ashley J.; Quackenbush John; Glass Kimberly

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Diet-induced weight loss leads to a switch in gene regulatory network control in the rectal mucosa

机译：饮食引起的体重减轻导致直肠黏膜基因调控网络控制的转换

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Background: Weight loss may decrease risk of colorectal cancer in obese individuals, yet its effect in the colorectum is not well understood. We used integrative network modeling, Passing Attributes between Networks for Data Assimilation, to estimate transcriptional regulatory network models from mRNA expression levels from rectal mucosa biopsies measured pre- and post-weight loss in 10 obese, pre-menopausal women.

机译：背景：体重减轻可能会降低肥胖者患结直肠癌的风险，但其在结直肠中的作用尚不清楚。我们使用了集成网络建模，即“数据同化网络之间的传递属性”，根据直肠黏膜活检组织中10位肥胖，绝经前妇女体重减轻前后的mRNA表达水平估算转录调控网络模型。

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《Genomics》 |2016年第4期|共8页
作者
Vargas Ashley J.; Quackenbush John; Glass Kimberly;
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原文格式 PDF
正文语种 eng
中图分类医学遗传学;
关键词
Weight loss; Colorectal cancer; Colorectum; Diet; Gene network; Gene regulation; Diet;

机译：减肥;大肠癌;大肠;饮食;基因网络;基因调控;饮食;

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1. Diet-induced weight loss leads to a switch in gene regulatory network control in the rectal mucosa [J] . Vargas Ashley J., Quackenbush John, Glass Kimberly Genomics . 2016,第3a4期

机译：饮食引起的体重减轻导致直肠黏膜基因调控网络控制的转换
2. Diet-induced weight loss leads to a switch in gene regulatory network control in the rectal mucosa [J] . Ashley J. Vargas, John Quackenbush, Kimberly Glass Genomics . 2016,第2016期

机译：饮食引起的体重减轻导致直肠黏膜基因调控网络控制的转换
3. Diet-induced weight loss leads to a switch in gene regulatory network control in the rectal mucosa [J] . Vargas Ashley J., Quackenbush John, Glass Kimberly Genomics . 2016,第3a4期

机译：饮食诱导的体重减轻导致直肠粘膜中基因调节网络控制的开关
4. Evolving Reactive Controller for a Modular Robot: Benefits of the Property of State-Switching in Fractal Gene Regulatory Networks [C] . Payam Zahadat, Thomas Schmickl, Karl Crailsheim International conference on simulation of adaptive behavior . 2012

机译：模块化机器人的不断发展的无功控制器：分形基因调控网络中状态切换特性的好处
5. Expression of cohesin proteins and nano-architectural changes in rectal mucosa to assess risk of colon cancer based on field carcinogenesis. [D] . Davis, Ari B. 2014

机译：黏膜黏附蛋白的表达和直肠黏膜的纳米结构变化，以评估基于田间癌变的结肠癌风险。
6. Diet-induced weight loss leads to a switch in gene regulatory network control in the rectal mucosa [O] . Ashley J. Vargas, John Quackenbush, Kimberly Glass -1

机译：饮食引起的体重减轻导致直肠黏膜基因调控网络控制的转换
7. Diet-induced weight loss leads to a switch in gene regulatory network control in the rectal mucosa [O] . Vargas Ashley J., Quackenbush John, Glass Kimberly 2016

机译：饮食引起的体重减轻导致直肠黏膜基因调控网络控制的转换
8. Two Methods of Controlling Point-to-Point Loss Probabilities in a Circuit Switched Network [R] . Gajjala, M. 1985

机译：控制电路交换网络中点对点丢失概率的两种方法

Diet-induced weight loss leads to a switch in gene regulatory network control in the rectal mucosa

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