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Identification of gene expression changes in rabbit uterus during embryo implantation

机译：胚胎植入过程中兔子宫基因表达变化的鉴定

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Embryo implantation in the rabbit is unique in that a typical fusion type of implantation is employed, in which trophoblast cells adhere and fuse to the apical surface of uterine epithelial cells. In the present study, we analyzed global gene expression changes in the rabbit uterus during embryo implantation by using RNA-seq. We identified a total of 536 differentially expressed genes (fold change >2 and adjusted p-value <0.01), of which 266 genes were down-regulated and 270 genes were up-regulated at the implantation site compared to the inter-implantation site. Functional clustering revealed that cell adhesion is among top ranked enriched terms from both gene ontology and pathway analysis, highlighting the importance of cell adhesion during embryo implantation in rabbits. Through gene network analysis, we prioritized 9 genes using the hub gene method. Our study provides a valuable resource for in-depth understanding of the mechanism underlying embryo implantation in rabbits. (C) 2016 Elsevier Inc. All rights reserved.
机译：胚胎在兔中的植入是独特的，因为采用了典型的融合类型的植入，其中滋养层细胞粘附并融合到子宫上皮细胞的顶端表面。在本研究中，我们通过使用RNA序列分析了胚胎植入过程中兔子子宫中的整体基因表达变化。我们确定了总共536个差异表达基因（倍数变化> 2且调整后的p值<0.01），其中266个基因被下调，而270个基因在植入位点相比于植入间位点被上调。功能聚类显示，细胞粘附是基因本体论和途径分析中排名最高的富集术语之一，突显了在兔胚胎植入过程中细胞粘附的重要性。通过基因网络分析，我们使用中枢基因方法对9个基因进行了优先排序。我们的研究为深入了解兔子胚胎植入的机制提供了宝贵的资源。 （C）2016 Elsevier Inc.保留所有权利。

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