• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genomics >Mapping and structure of DMXL1, a human homologue of the DmX gene from Drosophila melanogaster coding for a WD repeat protein.
【24h】

Mapping and structure of DMXL1, a human homologue of the DmX gene from Drosophila melanogaster coding for a WD repeat protein.

机译：DMXL1的图和结构，DMXL1是黑腹果蝇DmX基因的人类同源物，编码WD重复蛋白。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The DmX gene was recently isolated from the X chromosome of Drosophila melanogaster. TBLASTN searches of the dbEST databases revealed sequences with a high level of similarity to DmX in a variety of different species, including insects, nematodes, and mammals showing that DmX is an evolutionarily highly conserved gene. Here we describe the cloning of the cDNA and the chromosomal localization of one of the human homologues of DmX, Dmx-like 1 (DMXL1). The human DMXL1 gene codes for a large mRNA of 11 kb with an open reading frame of 3027 amino acids. The putative protein belongs to the superfamily of WD repeat proteins, which have mostly regulatory functions. The DMXL1 protein contains an exceptionally large number of WD repeat units. The DMXL1 gene is located on chromosome 5q22 as determined by radiation hybrid mapping and fluorescence in situ hybridization. Although the function of the DMXL1 gene and its homologues in other species remains to be discovered, the high level of evolutionary conservation together with the unusual structure suggests that it probably has an important function. Copyright 2000 Academic Press.
机译：DmX基因是最近从果蝇X染色体分离的。 dbEST数据库的TBLASTN搜索显示了在许多不同物种（包括昆虫，线虫和哺乳动物）中与DmX具有高度相似性的序列，表明DmX是进化上高度保守的基因。在这里，我们描述了cDNA的克隆和DmX，Dmx样1（DMXL1）的人类同源物之一的染色体定位。人DMXL1基因编码11 kb的大mRNA，并带有3027个氨基酸的开放阅读框。推定的蛋白质属于WD重复蛋白质的超家族，其主要具有调节功能。 DMXL1蛋白包含大量的WD重复单元。 DMXL1基因位于5q22染色体上，这是通过放射杂交图谱和荧光原位杂交确定的。尽管DMXL1基因及其同源物在其他物种中的功能仍有待发现，但高水平的进化保守性以及异常的结构表明它可能具有重要的功能。版权所有2000学术出版社。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号